A PKC wave follows the calcium wave after activation of Xenopus eggs
Calcium waves are well-known hallmarks of egg activation that trigger resumption of the cell cycle and development of the embryo. These waves rapidly and efficiently assure that activation signals are transmitted to all regions of the egg. Although the mechanism by which the calcium wave propagates...
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| Veröffentlicht in: | Differentiation (London) 2004-02, Vol.72 (1), p.41-47 |
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| creator | Larabell, Carolyn A. Rowning, Brian A. Moon, Randall T. |
| description | Calcium waves are well-known hallmarks of egg activation that trigger resumption of the cell cycle and development of the embryo. These waves rapidly and efficiently assure that activation signals are transmitted to all regions of the egg. Although the mechanism by which the calcium wave propagates across an egg as large as that of
Xenopus is not known, two models prevail. One model is a wave of calcium-induced calcium release (CICR) and the other is propagation by inositol-induced calcium release (IICR). IICR requires a wave of phosphatidylinositol 4,5-bisphosphate (PIP
2) hydrolysis, generating two second messengers, IP
3, which then releases calcium and DAG, which activates protein kinase C (PKC). We show here that a wave of PKC-green fluorescent protein travels across the egg immediately following, and at the same velocity as, the calcium wave. This is the first example of a PKC wave in a vertebrate egg and supports the IICR model of wave propagation. |
| doi_str_mv | 10.1111/j.1432-0436.2004.07201005.x |
| format | Article |
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Xenopus is not known, two models prevail. One model is a wave of calcium-induced calcium release (CICR) and the other is propagation by inositol-induced calcium release (IICR). IICR requires a wave of phosphatidylinositol 4,5-bisphosphate (PIP
2) hydrolysis, generating two second messengers, IP
3, which then releases calcium and DAG, which activates protein kinase C (PKC). We show here that a wave of PKC-green fluorescent protein travels across the egg immediately following, and at the same velocity as, the calcium wave. This is the first example of a PKC wave in a vertebrate egg and supports the IICR model of wave propagation.</description><identifier>ISSN: 0301-4681</identifier><identifier>EISSN: 1432-0436</identifier><identifier>DOI: 10.1111/j.1432-0436.2004.07201005.x</identifier><identifier>PMID: 15008825</identifier><language>eng</language><publisher>Oxford, UK: Elsevier B.V</publisher><subject>Animals ; Calcium Signaling ; Cells, Cultured ; development ; diacylglycerol ; Diglycerides - metabolism ; Embryo, Nonmammalian ; Enzyme Activation ; Female ; fertilization ; Green Fluorescent Proteins ; inositol 1,4,5-trisphosphate ; Inositol 1,4,5-Trisphosphate - metabolism ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Oocytes - metabolism ; Oocytes - physiology ; phosphatidylinositol 4,5-bisphosphate ; Phosphatidylinositol 4,5-Diphosphate - metabolism ; Protein Kinase C - genetics ; Protein Kinase C - immunology ; Protein Kinase C - metabolism ; Xenopus laevis - embryology ; Xenopus laevis - metabolism ; Zygote - metabolism</subject><ispartof>Differentiation (London), 2004-02, Vol.72 (1), p.41-47</ispartof><rights>2004 International Society of Differentiation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5065-ea55943eb0c55fa99715e8d75442a8b7ca9e84de9436adb3ac1ee6951d2246f73</citedby><cites>FETCH-LOGICAL-c5065-ea55943eb0c55fa99715e8d75442a8b7ca9e84de9436adb3ac1ee6951d2246f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-0436.2004.07201005.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1111/j.1432-0436.2004.07201005.x$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,1417,3549,27923,27924,45573,45574,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15008825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Larabell, Carolyn A.</creatorcontrib><creatorcontrib>Rowning, Brian A.</creatorcontrib><creatorcontrib>Moon, Randall T.</creatorcontrib><title>A PKC wave follows the calcium wave after activation of Xenopus eggs</title><title>Differentiation (London)</title><addtitle>Differentiation</addtitle><description>Calcium waves are well-known hallmarks of egg activation that trigger resumption of the cell cycle and development of the embryo. These waves rapidly and efficiently assure that activation signals are transmitted to all regions of the egg. Although the mechanism by which the calcium wave propagates across an egg as large as that of
Xenopus is not known, two models prevail. One model is a wave of calcium-induced calcium release (CICR) and the other is propagation by inositol-induced calcium release (IICR). IICR requires a wave of phosphatidylinositol 4,5-bisphosphate (PIP
2) hydrolysis, generating two second messengers, IP
3, which then releases calcium and DAG, which activates protein kinase C (PKC). We show here that a wave of PKC-green fluorescent protein travels across the egg immediately following, and at the same velocity as, the calcium wave. This is the first example of a PKC wave in a vertebrate egg and supports the IICR model of wave propagation.</description><subject>Animals</subject><subject>Calcium Signaling</subject><subject>Cells, Cultured</subject><subject>development</subject><subject>diacylglycerol</subject><subject>Diglycerides - metabolism</subject><subject>Embryo, Nonmammalian</subject><subject>Enzyme Activation</subject><subject>Female</subject><subject>fertilization</subject><subject>Green Fluorescent Proteins</subject><subject>inositol 1,4,5-trisphosphate</subject><subject>Inositol 1,4,5-Trisphosphate - metabolism</subject><subject>Luminescent Proteins - genetics</subject><subject>Luminescent Proteins - metabolism</subject><subject>Oocytes - metabolism</subject><subject>Oocytes - physiology</subject><subject>phosphatidylinositol 4,5-bisphosphate</subject><subject>Phosphatidylinositol 4,5-Diphosphate - metabolism</subject><subject>Protein Kinase C - genetics</subject><subject>Protein Kinase C - immunology</subject><subject>Protein Kinase C - metabolism</subject><subject>Xenopus laevis - embryology</subject><subject>Xenopus laevis - metabolism</subject><subject>Zygote - metabolism</subject><issn>0301-4681</issn><issn>1432-0436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMobk7_ggQE71qTNukHXsk-dDjQCwXvQpqezoy2mU27j39vSze91dychPOcN4cHoRtKXNqeu5VLme85hPmB6xHCXBJ6hBLC3d0JGv70TtGQ-IQ6LIjoAF1YuyKERIFHz9GA8vYaeXyIJg_49XmMt3IDODN5brYW15-AlcyVboq-IbMaKixVrTey1qbEJsMfUJp1YzEsl_YSnWUyt3B1qCP0Ppu-jZ-cxcvjfPywcBQnAXdAch4zHxKiOM9kHIeUQ5SGnDFPRkmoZAwRS6FlApkmvlQUIIg5TT2PBVnoj9Btn7uuzFcDthaFtgryXJZgGitCGtI4DlgL3vegqoy1FWRiXelCVntBiegkipXoRIlOlOgkiqNEsWunrw_fNEkB6e_swVoLTHpgq3PY_ydbTOaz46uNmfYx0DrbaKiEVRpKBamuQNUiNfpP-34DQqaWHQ</recordid><startdate>200402</startdate><enddate>200402</enddate><creator>Larabell, Carolyn A.</creator><creator>Rowning, Brian A.</creator><creator>Moon, Randall T.</creator><general>Elsevier B.V</general><general>Blackwell Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200402</creationdate><title>A PKC wave follows the calcium wave after activation of Xenopus eggs</title><author>Larabell, Carolyn A. ; Rowning, Brian A. ; Moon, Randall T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5065-ea55943eb0c55fa99715e8d75442a8b7ca9e84de9436adb3ac1ee6951d2246f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Calcium Signaling</topic><topic>Cells, Cultured</topic><topic>development</topic><topic>diacylglycerol</topic><topic>Diglycerides - metabolism</topic><topic>Embryo, Nonmammalian</topic><topic>Enzyme Activation</topic><topic>Female</topic><topic>fertilization</topic><topic>Green Fluorescent Proteins</topic><topic>inositol 1,4,5-trisphosphate</topic><topic>Inositol 1,4,5-Trisphosphate - metabolism</topic><topic>Luminescent Proteins - genetics</topic><topic>Luminescent Proteins - metabolism</topic><topic>Oocytes - metabolism</topic><topic>Oocytes - physiology</topic><topic>phosphatidylinositol 4,5-bisphosphate</topic><topic>Phosphatidylinositol 4,5-Diphosphate - metabolism</topic><topic>Protein Kinase C - genetics</topic><topic>Protein Kinase C - immunology</topic><topic>Protein Kinase C - metabolism</topic><topic>Xenopus laevis - embryology</topic><topic>Xenopus laevis - metabolism</topic><topic>Zygote - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larabell, Carolyn A.</creatorcontrib><creatorcontrib>Rowning, Brian A.</creatorcontrib><creatorcontrib>Moon, Randall T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Differentiation (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Larabell, Carolyn A.</au><au>Rowning, Brian A.</au><au>Moon, Randall T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A PKC wave follows the calcium wave after activation of Xenopus eggs</atitle><jtitle>Differentiation (London)</jtitle><addtitle>Differentiation</addtitle><date>2004-02</date><risdate>2004</risdate><volume>72</volume><issue>1</issue><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0301-4681</issn><eissn>1432-0436</eissn><abstract>Calcium waves are well-known hallmarks of egg activation that trigger resumption of the cell cycle and development of the embryo. These waves rapidly and efficiently assure that activation signals are transmitted to all regions of the egg. Although the mechanism by which the calcium wave propagates across an egg as large as that of
Xenopus is not known, two models prevail. One model is a wave of calcium-induced calcium release (CICR) and the other is propagation by inositol-induced calcium release (IICR). IICR requires a wave of phosphatidylinositol 4,5-bisphosphate (PIP
2) hydrolysis, generating two second messengers, IP
3, which then releases calcium and DAG, which activates protein kinase C (PKC). We show here that a wave of PKC-green fluorescent protein travels across the egg immediately following, and at the same velocity as, the calcium wave. This is the first example of a PKC wave in a vertebrate egg and supports the IICR model of wave propagation.</abstract><cop>Oxford, UK</cop><pub>Elsevier B.V</pub><pmid>15008825</pmid><doi>10.1111/j.1432-0436.2004.07201005.x</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Calcium Signaling Cells, Cultured development diacylglycerol Diglycerides - metabolism Embryo, Nonmammalian Enzyme Activation Female fertilization Green Fluorescent Proteins inositol 1,4,5-trisphosphate Inositol 1,4,5-Trisphosphate - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Oocytes - metabolism Oocytes - physiology phosphatidylinositol 4,5-bisphosphate Phosphatidylinositol 4,5-Diphosphate - metabolism Protein Kinase C - genetics Protein Kinase C - immunology Protein Kinase C - metabolism Xenopus laevis - embryology Xenopus laevis - metabolism Zygote - metabolism |
| title | A PKC wave follows the calcium wave after activation of Xenopus eggs |
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