Effect of rofecoxib on platelet aggregation and blood loss in gynaecological and breast surgery compared with diclofenac

Non-selective cyclooxygenase (COX) inhibitors or non-steroidal anti- inflammatory drugs (NSAIDs) are frequently omitted for perioperative pain relief because of potential side-effects. COX-2-selective inhibitors may have a more favourable side-effect profile. This study tested the hypothesis that th...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2004-04, Vol.92 (4), p.523-531
Hauptverfasser:	Hegi, T.R., Bombeli, T, Seifert, B, Baumann, P.C., Haller, U, Zalunardo, M.P., Pasch, T, Spahn, D.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged analgesia analgesia, postoperative analgesics non-opioid, diclofenac analgesics non-opioid, rofecoxib analgesics non‐opioid Analgesics, Opioid - therapeutic use Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy antagonists antagonists, cyclooxygenase type 2 antagonist Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antiemetics - therapeutic use Biological and medical sciences blood Blood Loss, Surgical - prevention & control blood, platelet aggregation, drug effects Breast Neoplasms - surgery Breast surgery Cyclooxygenase Inhibitors - pharmacology cyclooxygenase type 2 antagonist diclofenac Diclofenac - pharmacology Double-Blind Method drug effects Female Hemostasis, Surgical - methods Humans Hysterectomy Lactones - pharmacology Medical sciences Middle Aged Morphine - therapeutic use non-steroidal anti-inflammatory drugs Pain Measurement platelet aggregation Platelet Aggregation - drug effects postoperative Pregnancy Prospective Studies rofecoxib Sulfones Treatment Outcome
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