Cytochrome P450 3A4 and P‐glycoprotein Expression in Human Small Intestinal Enterocytes and Hepatocytes: A Comparative Analysis in Paired Tissue Specimens

Objectives Our objectives were to determine the content of cytochrome P450 (CYP) 3A4, CYP3A5, and P‐glycoprotein and to measure CYP3A4‐dependent catalytic activity in paired human small intestinal and liver specimens. Methods Samples of duodenum or proximal jejunum and liver wedge biopsy specimens w...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2004-03, Vol.75 (3), p.172-183
Hauptverfasser:	Richter, Oliver, Burk, Oliver, Fromm, Martin F., Thon, Klaus P., Eichelbaum, Michel, Kivistö, Kari T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analytical, structural and metabolic biochemistry ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Biological and medical sciences Blotting, Western Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Enterocytes - enzymology Enterocytes - metabolism Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Hepatocytes - enzymology Hepatocytes - metabolism Humans Intestine, Small - enzymology Intestine, Small - metabolism Male Middle Aged Oxidoreductases Statistics, Nonparametric
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