Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma
Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous cell carcinoma (SCC). Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale...
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| Veröffentlicht in: | Clinical cancer research 2004-03, Vol.10 (5), p.1678-1684 |
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| creator | CHANG, Bryan W KIM, David H KOWALSKI, Diane P BURLESON, Joseph A SON, Yung H WILSON, Lynn D HAFFTY, Bruce G |
| description | Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous
cell carcinoma (SCC).
Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New
Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external beam radiotherapy or gross total
surgical resection and postoperative radiotherapy. A microarray of archival tumor tissue was constructed and stained with
monoclonal antibodies directed against COX-2 and scored for intensity by a pathologist blinded to the clinical outcomes of
the patients. COX-2 immunoreactivity and clinicopathological data were analyzed with respect to survival endpoints using bivariate
and multivariate techniques.
Results: Frequency of COX-2 overexpression was 45%. In multivariate analysis, COX-2 positivity predicted poor 3-year survival ( P = 0.02; odds ratio = 0.41; 95% confidence interval, 0.20–0.84). Increasing age was significantly associated with increased
3-year survival ( P = 0.03; odds ratio = 1.04; 95% confidence interval, 1.004–1.09). Positive COX-2 status trended toward predicting decreased
3-year disease-free survival.
Conclusions: COX-2 was the most important predictor of poor survival in this patient cohort. In patients with oropharyngeal SCC treated
with external-beam radiation therapy, overexpression of COX-2 may affect clinical outcome, and COX-2 may therefore prove valuable
both as a prognostic factor and as a therapeutic target. |
| doi_str_mv | 10.1158/1078-0432.CCR-03-0354 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71718809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71718809</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-110ea7c2d97bfe4a85dbff220f6052d1f42cef844f068564afb7b34285391add3</originalsourceid><addsrcrecordid>eNpNkF1LwzAUhoMobk5_gtIbxZtqTpq02aUUv2Cg-HEd0jTpIm2zJRu6f2_qJgoHci6ec86bB6FTwFcAjF8DLniKaUauyvIlxVksRvfQGBgr0ozkbD_2v8wIHYXwgTFQwPQQjYDFFsN0jN6evWt6F1ZWJa-26a2xSvZKJ84k5Ua1zn1tGt3LoFOS2D558m4xl37TN1q2yetyLTu3Dkmp2zYppVe2d508RgdGtkGf7N4Jer-7fSsf0tnT_WN5M0sV5bBKAbCWhSL1tKiMppKzujKGEGxyzEgNhhKlDafU4JyznEpTFVVGCWfZFGRdZxN0sd278G651mElOhtUjCJ7HVOJAgrgHE8jyLag8i4Er41YeNvFbwjAYtApBlViUCWiToEzMeiMc2e7A-uq0_Xf1M5fBM53gAxKtsZHdzb84xjjDIZFl1tubpv5p_Va_Fj2Xgcdrc2HHExAXvDsG7pdjAk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71718809</pqid></control><display><type>article</type><title>Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>CHANG, Bryan W ; KIM, David H ; KOWALSKI, Diane P ; BURLESON, Joseph A ; SON, Yung H ; WILSON, Lynn D ; HAFFTY, Bruce G</creator><creatorcontrib>CHANG, Bryan W ; KIM, David H ; KOWALSKI, Diane P ; BURLESON, Joseph A ; SON, Yung H ; WILSON, Lynn D ; HAFFTY, Bruce G</creatorcontrib><description>Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous
cell carcinoma (SCC).
Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New
Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external beam radiotherapy or gross total
surgical resection and postoperative radiotherapy. A microarray of archival tumor tissue was constructed and stained with
monoclonal antibodies directed against COX-2 and scored for intensity by a pathologist blinded to the clinical outcomes of
the patients. COX-2 immunoreactivity and clinicopathological data were analyzed with respect to survival endpoints using bivariate
and multivariate techniques.
Results: Frequency of COX-2 overexpression was 45%. In multivariate analysis, COX-2 positivity predicted poor 3-year survival ( P = 0.02; odds ratio = 0.41; 95% confidence interval, 0.20–0.84). Increasing age was significantly associated with increased
3-year survival ( P = 0.03; odds ratio = 1.04; 95% confidence interval, 1.004–1.09). Positive COX-2 status trended toward predicting decreased
3-year disease-free survival.
Conclusions: COX-2 was the most important predictor of poor survival in this patient cohort. In patients with oropharyngeal SCC treated
with external-beam radiation therapy, overexpression of COX-2 may affect clinical outcome, and COX-2 may therefore prove valuable
both as a prognostic factor and as a therapeutic target.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-03-0354</identifier><identifier>PMID: 15014019</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Carcinoma, Squamous Cell - surgery ; Cohort Studies ; Cyclooxygenase 2 ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Isoenzymes - metabolism ; Male ; Medical sciences ; Membrane Proteins ; Middle Aged ; Oropharyngeal Neoplasms - enzymology ; Oropharyngeal Neoplasms - mortality ; Oropharyngeal Neoplasms - pathology ; Oropharyngeal Neoplasms - radiotherapy ; Oropharyngeal Neoplasms - surgery ; Pharmacology. Drug treatments ; Prognosis ; Prostaglandin-Endoperoxide Synthases - metabolism ; Retrospective Studies ; Survival Analysis ; Time Factors ; Tumors</subject><ispartof>Clinical cancer research, 2004-03, Vol.10 (5), p.1678-1684</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-110ea7c2d97bfe4a85dbff220f6052d1f42cef844f068564afb7b34285391add3</citedby><cites>FETCH-LOGICAL-c481t-110ea7c2d97bfe4a85dbff220f6052d1f42cef844f068564afb7b34285391add3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15558514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15014019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHANG, Bryan W</creatorcontrib><creatorcontrib>KIM, David H</creatorcontrib><creatorcontrib>KOWALSKI, Diane P</creatorcontrib><creatorcontrib>BURLESON, Joseph A</creatorcontrib><creatorcontrib>SON, Yung H</creatorcontrib><creatorcontrib>WILSON, Lynn D</creatorcontrib><creatorcontrib>HAFFTY, Bruce G</creatorcontrib><title>Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous
cell carcinoma (SCC).
Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New
Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external beam radiotherapy or gross total
surgical resection and postoperative radiotherapy. A microarray of archival tumor tissue was constructed and stained with
monoclonal antibodies directed against COX-2 and scored for intensity by a pathologist blinded to the clinical outcomes of
the patients. COX-2 immunoreactivity and clinicopathological data were analyzed with respect to survival endpoints using bivariate
and multivariate techniques.
Results: Frequency of COX-2 overexpression was 45%. In multivariate analysis, COX-2 positivity predicted poor 3-year survival ( P = 0.02; odds ratio = 0.41; 95% confidence interval, 0.20–0.84). Increasing age was significantly associated with increased
3-year survival ( P = 0.03; odds ratio = 1.04; 95% confidence interval, 1.004–1.09). Positive COX-2 status trended toward predicting decreased
3-year disease-free survival.
Conclusions: COX-2 was the most important predictor of poor survival in this patient cohort. In patients with oropharyngeal SCC treated
with external-beam radiation therapy, overexpression of COX-2 may affect clinical outcome, and COX-2 may therefore prove valuable
both as a prognostic factor and as a therapeutic target.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cohort Studies</subject><subject>Cyclooxygenase 2</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Isoenzymes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins</subject><subject>Middle Aged</subject><subject>Oropharyngeal Neoplasms - enzymology</subject><subject>Oropharyngeal Neoplasms - mortality</subject><subject>Oropharyngeal Neoplasms - pathology</subject><subject>Oropharyngeal Neoplasms - radiotherapy</subject><subject>Oropharyngeal Neoplasms - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>Prostaglandin-Endoperoxide Synthases - metabolism</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMobk5_gtIbxZtqTpq02aUUv2Cg-HEd0jTpIm2zJRu6f2_qJgoHci6ec86bB6FTwFcAjF8DLniKaUauyvIlxVksRvfQGBgr0ozkbD_2v8wIHYXwgTFQwPQQjYDFFsN0jN6evWt6F1ZWJa-26a2xSvZKJ84k5Ua1zn1tGt3LoFOS2D558m4xl37TN1q2yetyLTu3Dkmp2zYppVe2d508RgdGtkGf7N4Jer-7fSsf0tnT_WN5M0sV5bBKAbCWhSL1tKiMppKzujKGEGxyzEgNhhKlDafU4JyznEpTFVVGCWfZFGRdZxN0sd278G651mElOhtUjCJ7HVOJAgrgHE8jyLag8i4Er41YeNvFbwjAYtApBlViUCWiToEzMeiMc2e7A-uq0_Xf1M5fBM53gAxKtsZHdzb84xjjDIZFl1tubpv5p_Va_Fj2Xgcdrc2HHExAXvDsG7pdjAk</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>CHANG, Bryan W</creator><creator>KIM, David H</creator><creator>KOWALSKI, Diane P</creator><creator>BURLESON, Joseph A</creator><creator>SON, Yung H</creator><creator>WILSON, Lynn D</creator><creator>HAFFTY, Bruce G</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma</title><author>CHANG, Bryan W ; KIM, David H ; KOWALSKI, Diane P ; BURLESON, Joseph A ; SON, Yung H ; WILSON, Lynn D ; HAFFTY, Bruce G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-110ea7c2d97bfe4a85dbff220f6052d1f42cef844f068564afb7b34285391add3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cohort Studies</topic><topic>Cyclooxygenase 2</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Isoenzymes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins</topic><topic>Middle Aged</topic><topic>Oropharyngeal Neoplasms - enzymology</topic><topic>Oropharyngeal Neoplasms - mortality</topic><topic>Oropharyngeal Neoplasms - pathology</topic><topic>Oropharyngeal Neoplasms - radiotherapy</topic><topic>Oropharyngeal Neoplasms - surgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>Prostaglandin-Endoperoxide Synthases - metabolism</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Time Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHANG, Bryan W</creatorcontrib><creatorcontrib>KIM, David H</creatorcontrib><creatorcontrib>KOWALSKI, Diane P</creatorcontrib><creatorcontrib>BURLESON, Joseph A</creatorcontrib><creatorcontrib>SON, Yung H</creatorcontrib><creatorcontrib>WILSON, Lynn D</creatorcontrib><creatorcontrib>HAFFTY, Bruce G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHANG, Bryan W</au><au>KIM, David H</au><au>KOWALSKI, Diane P</au><au>BURLESON, Joseph A</au><au>SON, Yung H</au><au>WILSON, Lynn D</au><au>HAFFTY, Bruce G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>10</volume><issue>5</issue><spage>1678</spage><epage>1684</epage><pages>1678-1684</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous
cell carcinoma (SCC).
Experimental Design: This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New
Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external beam radiotherapy or gross total
surgical resection and postoperative radiotherapy. A microarray of archival tumor tissue was constructed and stained with
monoclonal antibodies directed against COX-2 and scored for intensity by a pathologist blinded to the clinical outcomes of
the patients. COX-2 immunoreactivity and clinicopathological data were analyzed with respect to survival endpoints using bivariate
and multivariate techniques.
Results: Frequency of COX-2 overexpression was 45%. In multivariate analysis, COX-2 positivity predicted poor 3-year survival ( P = 0.02; odds ratio = 0.41; 95% confidence interval, 0.20–0.84). Increasing age was significantly associated with increased
3-year survival ( P = 0.03; odds ratio = 1.04; 95% confidence interval, 1.004–1.09). Positive COX-2 status trended toward predicting decreased
3-year disease-free survival.
Conclusions: COX-2 was the most important predictor of poor survival in this patient cohort. In patients with oropharyngeal SCC treated
with external-beam radiation therapy, overexpression of COX-2 may affect clinical outcome, and COX-2 may therefore prove valuable
both as a prognostic factor and as a therapeutic target.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15014019</pmid><doi>10.1158/1078-0432.CCR-03-0354</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical cancer research, 2004-03, Vol.10 (5), p.1678-1684 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - surgery Cohort Studies Cyclooxygenase 2 Female Follow-Up Studies Humans Immunohistochemistry Isoenzymes - metabolism Male Medical sciences Membrane Proteins Middle Aged Oropharyngeal Neoplasms - enzymology Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - radiotherapy Oropharyngeal Neoplasms - surgery Pharmacology. Drug treatments Prognosis Prostaglandin-Endoperoxide Synthases - metabolism Retrospective Studies Survival Analysis Time Factors Tumors |
| title | Prognostic Significance of Cyclooxygenase-2 in Oropharyngeal Squamous Cell Carcinoma |
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