A new method for analysis of AZT-triphosphate and nucleotide-triphosphates

We have developed a new method based on matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) for analysis of zidovudine-triphosphate and (deoxy)nucleotide-triphosphates, which ultimately can be used for nucleoside reverse transcriptase inhibitor (NRTI) treatm...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-02, Vol.315 (1), p.151-159
Hauptverfasser:	van Kampen, Jeroen J.A, Fraaij, Pieter L.A, Hira, Vishal, van Rossum, Annemarie M.C, Hartwig, Nico G, de Groot, Ronald, Luider, Theo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analysis Anti-HIV Agents - analysis Anti-HIV Agents - chemistry Children Dideoxynucleotides Guanosine Triphosphate - analogs & derivatives Guanosine Triphosphate - analysis HIV-1/AIDS Human immunodeficiency virus 1 Humans Intracellular Leukocytes, Mononuclear - chemistry MALDI NRTI Nucleotide Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Thymine Nucleotides - analysis Thymine Nucleotides - chemistry Triphosphate Zidovudine - analogs & derivatives Zidovudine - analysis Zidovudine - chemistry
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