Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity

99mTc(V)- d, l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant d...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2004-02, Vol.34 (2), p.285-293
Hauptverfasser:	Nikolić, N, Veselinović, D, Vladimirov, S, Karljiković-Rajić, K, Lingeman, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Butanones - chemical synthesis Butanones - chemistry Chiral ligand-exchange chromatography (CLEC) Chromatography, Liquid - methods Diastereoselective reduction Diastereo–enantio separation Exametazime (HM-PAO) synthesis Fundamental and applied biological sciences. Psychology General pharmacology Medical sciences Pharmacology. Drug treatments Spectrophotometry, Ultraviolet - methods Stereoisomerism
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