Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release

Bacterial DNA (bDNA) and lipopolysaccharide (LPS) are potent activators of immune cells such as monocytes and macrophages, which contribute to systemic inflammatory response syndrome (SIRS) and sepsis. To date, no effective anti-sepsis drugs have been developed for clinical use. Chloroquine (CQ), a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International immunopharmacology 2004-02, Vol.4 (2), p.223-234
Hauptverfasser:	Hong, Zhou, Jiang, Zheng, Liangxi, Wang, Guofu, Ding, Ping, Luo, Yongling, Lu, Wendong, Pan, Minghai, Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Cell Line Chloroquine Chloroquine - pharmacology Chloroquine - therapeutic use CpG ODN Cytokines - biosynthesis Cytokines - immunology Disease Models, Animal DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Escherichia coli Female Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lipopolysaccharides LPS Male Medical sciences Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Mice Mice, Inbred BALB C NF-kappa B - immunology Oligodeoxyribonucleotides Pharmacology. Drug treatments Proinflammatory cytokines Rats Rats, Wistar Receptors, Cell Surface - biosynthesis Receptors, Cell Surface - genetics RNA, Messenger - analysis RNA, Messenger - biosynthesis Sepsis - drug therapy Systemic Inflammatory Response Syndrome - drug therapy Toll-Like Receptor 4 Toll-Like Receptor 9 Toll-Like Receptors Transcription Factor AP-1 - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!