Molecular basis for Rho GTPase signaling specificity
There is now considerable evidence for the involvement of aberrant Rho GTPase activation in breast cancer development. Like Ras, Rho GTPases function as signaling nodes regulated by diverse extracellular stimuli. Rho GTPase activation is facilitated by multiple regulatory proteins, in particular gua...
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| Veröffentlicht in: | Breast cancer research and treatment 2004-03, Vol.84 (1), p.61-71 |
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| container_title | Breast cancer research and treatment |
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| creator | Karnoub, Antoine E Symons, Marc Campbell, Sharon L Der, Channing J |
| description | There is now considerable evidence for the involvement of aberrant Rho GTPase activation in breast cancer development. Like Ras, Rho GTPases function as signaling nodes regulated by diverse extracellular stimuli. Rho GTPase activation is facilitated by multiple regulatory proteins, in particular guanine nucleotide exchange factors (GEFs) such as Dbl family proteins. Activated Rho GTPases in turn interact with and regulate a spectrum of functionally diverse downstream effectors, initiating a network of cytoplasmic and nuclear signaling cascades. Thus, Rho GTPases represent points of signaling convergence as well as relay switches that disseminate signaling divergence. In this review, we highlight issues relating to the structural basis by which Dbl family GEFs facilitate signaling convergence and Rho GTPase activation, and how Rho GTPases promote signal dissemination through downstream effectors. |
| doi_str_mv | 10.1023/b:brea.0000018427.84929.5c |
| format | Article |
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Like Ras, Rho GTPases function as signaling nodes regulated by diverse extracellular stimuli. Rho GTPase activation is facilitated by multiple regulatory proteins, in particular guanine nucleotide exchange factors (GEFs) such as Dbl family proteins. Activated Rho GTPases in turn interact with and regulate a spectrum of functionally diverse downstream effectors, initiating a network of cytoplasmic and nuclear signaling cascades. Thus, Rho GTPases represent points of signaling convergence as well as relay switches that disseminate signaling divergence. 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Like Ras, Rho GTPases function as signaling nodes regulated by diverse extracellular stimuli. Rho GTPase activation is facilitated by multiple regulatory proteins, in particular guanine nucleotide exchange factors (GEFs) such as Dbl family proteins. Activated Rho GTPases in turn interact with and regulate a spectrum of functionally diverse downstream effectors, initiating a network of cytoplasmic and nuclear signaling cascades. Thus, Rho GTPases represent points of signaling convergence as well as relay switches that disseminate signaling divergence. 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| subjects | Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - pathology Breast Neoplasms - physiopathology Cancer research Enzyme Activation - physiology Female GTPase-Activating Proteins - physiology Guanine Nucleotide Dissociation Inhibitors - physiology Guanine Nucleotide Exchange Factors - physiology Humans Mutation Proteins rho GTP-Binding Proteins - genetics rho GTP-Binding Proteins - physiology Signal Transduction - physiology |
| title | Molecular basis for Rho GTPase signaling specificity |
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