Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donation

Little is known about homocysteine metabolism in intestine. To address this question, we investigated homocysteine metabolism under conditions of folate adequacy and folate deprivation in the Caco-2 cell line, a model of human intestinal mucosal cells. Caco-2 cells were cultured in media enriched wi...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-04, Vol.286 (4), p.G588-G595
Hauptverfasser:	Townsend, Justin H, Davis, Steven R, Mackey, Amy D, Gregory, 3rd, Jesse F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - isolation & purification Amino Acids - metabolism Caco-2 Cells Culture Media Epithelial Cells - metabolism Folic Acid Deficiency - metabolism Homocysteine - metabolism Humans Intestines - cytology Intestines - metabolism Kinetics Methionine - metabolism Methylation Serine - metabolism
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