Infant pertussis deaths and the management of cardiovascular compromise
: Infants infected with Bordetella pertussis in the first few weeks of life are at risk of death from ‘overwhelming cardiovascular compromise despite intensive care support’. The mechanisms of this severe disease are not completely understood. Three case histories, including that of one infant who...
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| Veröffentlicht in: | Journal of paediatrics and child health 2004-04, Vol.40 (4), p.230-232 |
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| container_title | Journal of paediatrics and child health |
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| creator | McEniery, JA Delbridge, RG Reith, DM |
| description | : Infants infected with Bordetella pertussis in the first few weeks of life are at risk of death from ‘overwhelming cardiovascular compromise despite intensive care support’. The mechanisms of this severe disease are not completely understood. Three case histories, including that of one infant who survived, are presented. Two of the patients died despite intensive therapy with pressors and, in one child, milrinone. The third child survived following treatment with nitric oxide and sildenafil. Hence, sildenafil in combination with nitric oxide shows promise as a therapy for the haemodynamic consequences of pertussis toxaemia and this should prompt clinical trials for their efficacy for this condition. |
| doi_str_mv | 10.1111/j.1440-1754.2004.00344.x |
| format | Article |
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The mechanisms of this severe disease are not completely understood. Three case histories, including that of one infant who survived, are presented. Two of the patients died despite intensive therapy with pressors and, in one child, milrinone. The third child survived following treatment with nitric oxide and sildenafil. Hence, sildenafil in combination with nitric oxide shows promise as a therapy for the haemodynamic consequences of pertussis toxaemia and this should prompt clinical trials for their efficacy for this condition.</description><subject>Australia</subject><subject>Babies</subject><subject>Bordetella pertussis</subject><subject>Bordetella pertussis - isolation & purification</subject><subject>Cardiovascular Diseases - drug therapy</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular system</subject><subject>Death</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>milrinone</subject><subject>Nitric Oxide - therapeutic use</subject><subject>pertussis</subject><subject>Piperazines - therapeutic use</subject><subject>Purines</subject><subject>shock</subject><subject>sildenafil</subject><subject>Sildenafil Citrate</subject><subject>Sulfones</subject><subject>Treatment</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Whooping cough</subject><subject>Whooping Cough - complications</subject><subject>Whooping Cough - microbiology</subject><subject>Whooping Cough - mortality</subject><issn>1034-4810</issn><issn>1440-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkU1PwzAMhiMEYmPwF1BP3FqcNElbiQuaYAwhwQHOkZsmrFM_RtPC9u_J2ATHER9i2Y_9Sn4JCShE1L_rZUQ5h5AmgkcMgEcAMefR-oiMfxvHPvfVkKcURuTMuSUAMCHSUzKiAiATQo7JbN5YbPpgZbp-cK50QWGwX7gAmyLoFyaoscF3UxvPtDbQ2BVl-4lODxV2gW7rVdfWpTPn5MRi5czF_p-Qt_u71-lD-PQ8m09vn0LNmeQh5hZTWYCWMk9BAGKe5WCznEqaMyNoCoVkUhTacqPzREsrMs5YDNZQxCSekKvdXq_7MRjXK6-uTVVhY9rBqYT6AM4PgiKhWZymcBBkNOYsyagH0x2ou9a5zli16soau42ioLa2qKXaXl9tr6-2tqgfW9Taj17uNYa8NsXf4N4HD9zsgK-yMpt_L1aPL1OfxN_ZtptM</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>McEniery, JA</creator><creator>Delbridge, RG</creator><creator>Reith, DM</creator><general>Blackwell Science Pty</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Infant pertussis deaths and the management of cardiovascular compromise</title><author>McEniery, JA ; 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| fulltext | fulltext |
| identifier | ISSN: 1034-4810 |
| ispartof | Journal of paediatrics and child health, 2004-04, Vol.40 (4), p.230-232 |
| issn | 1034-4810 1440-1754 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Australia Babies Bordetella pertussis Bordetella pertussis - isolation & purification Cardiovascular Diseases - drug therapy Cardiovascular Diseases - etiology Cardiovascular system Death Drug Therapy, Combination Humans Infant Infant, Newborn Male milrinone Nitric Oxide - therapeutic use pertussis Piperazines - therapeutic use Purines shock sildenafil Sildenafil Citrate Sulfones Treatment Vasodilator Agents - therapeutic use Whooping cough Whooping Cough - complications Whooping Cough - microbiology Whooping Cough - mortality |
| title | Infant pertussis deaths and the management of cardiovascular compromise |
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