Sex-determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy
Aim: A number of studies for the measurement of cell‐free fetal DNA in maternal blood have been reported; however, their clinical significance has remained unclear. We proposed to clarify the relationship between fetal DNA levels and obstetrical disorders. Methods: One hundred and eighty‐five case...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2004-04, Vol.30 (2), p.148-154 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Shimada, Keiko Murakami, Kouichi Shozu, Makio Segawa, Tomoya Sumitani, Hiroshi Inoue, Masaki |
| description | Aim: A number of studies for the measurement of cell‐free fetal DNA in maternal blood have been reported; however, their clinical significance has remained unclear. We proposed to clarify the relationship between fetal DNA levels and obstetrical disorders.
Methods: One hundred and eighty‐five cases of normal pregnancy, ranging from 8 to 40 weeks’ gestation, and 70 cases of abnormal pregnancy were included. SRY levels in maternal plasma were quantified with a real‐time quantitative polymerase chain reaction.
Results: Sex‐determining region Y (SRY) levels and the number of patients with positive levels peaked at 33–36 weeks in normal pregnancy. The SRY levels in threatened abortion (11.6 ± 4.8 copies/mL to 0 ± 0, P |
| doi_str_mv | 10.1111/j.1447-0756.2003.00175.x |
| format | Article |
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Methods: One hundred and eighty‐five cases of normal pregnancy, ranging from 8 to 40 weeks’ gestation, and 70 cases of abnormal pregnancy were included. SRY levels in maternal plasma were quantified with a real‐time quantitative polymerase chain reaction.
Results: Sex‐determining region Y (SRY) levels and the number of patients with positive levels peaked at 33–36 weeks in normal pregnancy. The SRY levels in threatened abortion (11.6 ± 4.8 copies/mL to 0 ± 0, P < 0.05) and threatened preterm labor (44.6 ± 16.1 copies/mL to 15.9 ± 6.2, P < 0.01) were significantly higher than those of the normal group. In pre‐eclamptic patients, SRY levels were markedly higher than those of the normal group (173.2 ± 94.8 copies/mL to 22.4 ± 8.9, P < 0.05). Patients with premature separation of the placenta (266.8 ± 137.1 copies/mL to 4.9 ± 3.7, P < 0.05) and placenta previa (167.7 ± 32.4 copies/mL to 37.0 ± 17.3, p <0.01) also showed elevated SRY levels.
Conclusion: Sex‐determining region Y levels in maternal plasma were elevated in patients with an abnormal pregnancy, particularly those with placental injury of damage. These results suggested that increased SRY levels are consistently caused by the leak of fetal components, and thus the measurement of SRY levels in maternal plasma is useful for the evaluation of placental injuries.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2003.00175.x</identifier><identifier>PMID: 15009620</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>abnormal pregnancy ; Abortion, Threatened - blood ; Adult ; DNA - analysis ; DNA-Binding Proteins - blood ; Female ; fetal-maternal transfusion ; Fetus ; Gestational Age ; Humans ; maternal blood ; Nuclear Proteins ; Obstetric Labor, Premature - blood ; placental injury ; Polymerase Chain Reaction ; Pre-Eclampsia - blood ; Pregnancy ; Pregnancy Complications - blood ; sex-determining region Y levels ; Sex-Determining Region Y Protein ; Transcription Factors</subject><ispartof>The journal of obstetrics and gynaecology research, 2004-04, Vol.30 (2), p.148-154</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5055-659776190cc0f66497d6ab9d120dc8896f45b1908da9aa2c456ec3be8ed995ee3</citedby><cites>FETCH-LOGICAL-c5055-659776190cc0f66497d6ab9d120dc8896f45b1908da9aa2c456ec3be8ed995ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0756.2003.00175.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0756.2003.00175.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15009620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimada, Keiko</creatorcontrib><creatorcontrib>Murakami, Kouichi</creatorcontrib><creatorcontrib>Shozu, Makio</creatorcontrib><creatorcontrib>Segawa, Tomoya</creatorcontrib><creatorcontrib>Sumitani, Hiroshi</creatorcontrib><creatorcontrib>Inoue, Masaki</creatorcontrib><title>Sex-determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim: A number of studies for the measurement of cell‐free fetal DNA in maternal blood have been reported; however, their clinical significance has remained unclear. We proposed to clarify the relationship between fetal DNA levels and obstetrical disorders.
Methods: One hundred and eighty‐five cases of normal pregnancy, ranging from 8 to 40 weeks’ gestation, and 70 cases of abnormal pregnancy were included. SRY levels in maternal plasma were quantified with a real‐time quantitative polymerase chain reaction.
Results: Sex‐determining region Y (SRY) levels and the number of patients with positive levels peaked at 33–36 weeks in normal pregnancy. The SRY levels in threatened abortion (11.6 ± 4.8 copies/mL to 0 ± 0, P < 0.05) and threatened preterm labor (44.6 ± 16.1 copies/mL to 15.9 ± 6.2, P < 0.01) were significantly higher than those of the normal group. In pre‐eclamptic patients, SRY levels were markedly higher than those of the normal group (173.2 ± 94.8 copies/mL to 22.4 ± 8.9, P < 0.05). Patients with premature separation of the placenta (266.8 ± 137.1 copies/mL to 4.9 ± 3.7, P < 0.05) and placenta previa (167.7 ± 32.4 copies/mL to 37.0 ± 17.3, p <0.01) also showed elevated SRY levels.
Conclusion: Sex‐determining region Y levels in maternal plasma were elevated in patients with an abnormal pregnancy, particularly those with placental injury of damage. These results suggested that increased SRY levels are consistently caused by the leak of fetal components, and thus the measurement of SRY levels in maternal plasma is useful for the evaluation of placental injuries.</description><subject>abnormal pregnancy</subject><subject>Abortion, Threatened - blood</subject><subject>Adult</subject><subject>DNA - analysis</subject><subject>DNA-Binding Proteins - blood</subject><subject>Female</subject><subject>fetal-maternal transfusion</subject><subject>Fetus</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>maternal blood</subject><subject>Nuclear Proteins</subject><subject>Obstetric Labor, Premature - blood</subject><subject>placental injury</subject><subject>Polymerase Chain Reaction</subject><subject>Pre-Eclampsia - blood</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>sex-determining region Y levels</subject><subject>Sex-Determining Region Y Protein</subject><subject>Transcription Factors</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkNFOwjAUhhujEUVfwezKu82Wre1qvDFEUUNEEWO8arruYIZdhy0ovL2dEL21Nz3J__3nJB9CEcEJCe9slpAs4zHmlCU9jNMEY8JpstpBB7_BbpjTjMQ55qyDDr2ftZAg-T7qEIqxYD18gCZPsIpLWICrK1vZt8jBW9XY6DUy8AnGR5WNahViq0w0N8rX6jy6-lRmqRYtF2JV2MbVbRy6Vlm9PkJ7U2U8HG__Lnq-vpr0b-LhaHDbvxzGmmJKY0YF54wIrDWeMpYJXjJViJL0cKnzXLBpRosQ56USSvV0RhnotIAcSiEoQNpFp5u9c9d8LMEvZF15DcYoC83SS044YTyjAcw3oHaN9w6mcu6qWrm1JFi2RuVMtuJkK062RuWPUbkK1ZPtjWVRQ_lX3CoMwMUG-KoMrP-9WN6NBmEI9XhTr_wCVr915d4l42kgX-4HUmTp48N4OJDj9Buq_pO2</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Shimada, Keiko</creator><creator>Murakami, Kouichi</creator><creator>Shozu, Makio</creator><creator>Segawa, Tomoya</creator><creator>Sumitani, Hiroshi</creator><creator>Inoue, Masaki</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Sex-determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy</title><author>Shimada, Keiko ; Murakami, Kouichi ; Shozu, Makio ; Segawa, Tomoya ; Sumitani, Hiroshi ; Inoue, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5055-659776190cc0f66497d6ab9d120dc8896f45b1908da9aa2c456ec3be8ed995ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>abnormal pregnancy</topic><topic>Abortion, Threatened - blood</topic><topic>Adult</topic><topic>DNA - analysis</topic><topic>DNA-Binding Proteins - blood</topic><topic>Female</topic><topic>fetal-maternal transfusion</topic><topic>Fetus</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>maternal blood</topic><topic>Nuclear Proteins</topic><topic>Obstetric Labor, Premature - blood</topic><topic>placental injury</topic><topic>Polymerase Chain Reaction</topic><topic>Pre-Eclampsia - blood</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - blood</topic><topic>sex-determining region Y levels</topic><topic>Sex-Determining Region Y Protein</topic><topic>Transcription Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimada, Keiko</creatorcontrib><creatorcontrib>Murakami, Kouichi</creatorcontrib><creatorcontrib>Shozu, Makio</creatorcontrib><creatorcontrib>Segawa, Tomoya</creatorcontrib><creatorcontrib>Sumitani, Hiroshi</creatorcontrib><creatorcontrib>Inoue, Masaki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimada, Keiko</au><au>Murakami, Kouichi</au><au>Shozu, Makio</au><au>Segawa, Tomoya</au><au>Sumitani, Hiroshi</au><au>Inoue, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2004-04</date><risdate>2004</risdate><volume>30</volume><issue>2</issue><spage>148</spage><epage>154</epage><pages>148-154</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim: A number of studies for the measurement of cell‐free fetal DNA in maternal blood have been reported; however, their clinical significance has remained unclear. We proposed to clarify the relationship between fetal DNA levels and obstetrical disorders.
Methods: One hundred and eighty‐five cases of normal pregnancy, ranging from 8 to 40 weeks’ gestation, and 70 cases of abnormal pregnancy were included. SRY levels in maternal plasma were quantified with a real‐time quantitative polymerase chain reaction.
Results: Sex‐determining region Y (SRY) levels and the number of patients with positive levels peaked at 33–36 weeks in normal pregnancy. The SRY levels in threatened abortion (11.6 ± 4.8 copies/mL to 0 ± 0, P < 0.05) and threatened preterm labor (44.6 ± 16.1 copies/mL to 15.9 ± 6.2, P < 0.01) were significantly higher than those of the normal group. In pre‐eclamptic patients, SRY levels were markedly higher than those of the normal group (173.2 ± 94.8 copies/mL to 22.4 ± 8.9, P < 0.05). Patients with premature separation of the placenta (266.8 ± 137.1 copies/mL to 4.9 ± 3.7, P < 0.05) and placenta previa (167.7 ± 32.4 copies/mL to 37.0 ± 17.3, p <0.01) also showed elevated SRY levels.
Conclusion: Sex‐determining region Y levels in maternal plasma were elevated in patients with an abnormal pregnancy, particularly those with placental injury of damage. These results suggested that increased SRY levels are consistently caused by the leak of fetal components, and thus the measurement of SRY levels in maternal plasma is useful for the evaluation of placental injuries.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>15009620</pmid><doi>10.1111/j.1447-0756.2003.00175.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | abnormal pregnancy Abortion, Threatened - blood Adult DNA - analysis DNA-Binding Proteins - blood Female fetal-maternal transfusion Fetus Gestational Age Humans maternal blood Nuclear Proteins Obstetric Labor, Premature - blood placental injury Polymerase Chain Reaction Pre-Eclampsia - blood Pregnancy Pregnancy Complications - blood sex-determining region Y levels Sex-Determining Region Y Protein Transcription Factors |
| title | Sex-determining region Y levels in maternal plasma: Evaluation in abnormal pregnancy |
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