Thrombin inhibitors built on an azaphenylalanine scaffold

A series of azaphenylalanine derivatives were investigated as novel thrombin inhibitors based on the prodrug principle. By systematic structural modifications we have identified optimal groups for this series that led us to potent inhibitors of thrombin incorporating the benzamidine fragment at the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-03, Vol.14 (6), p.1563-1567
Hauptverfasser:	Zega, Anamarija, Mlinšek, Gregor, Šolmajer, Tomaž, Trampuš-Bakija, Alenka, Stegnar, Mojca, Urleb, Uroš
Format:	Artikel
Sprache:	eng
Schlagworte:	Aza Compounds - chemistry Aza Compounds - metabolism Azapeptidomimetics Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Medical sciences Pharmacology. Drug treatments Phenylalanine - chemistry Phenylalanine - metabolism Prodrug Protein Binding Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - metabolism Thrombin - antagonists & inhibitors Thrombin - metabolism Thrombin inhibitors
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