Propofol exhibits antiepileptic activity in hippocampal pyramidal neurons

Propofol was reported to exhibit an antiepileptic activity. This study was performed to investigate the effect of propofol on evoked and spontaneous seizure-like activity induced by the convulsant veratridine. Studies were performed on rat brain slices using conventional electrophysiological intrace...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2004-03, Vol.77 (3), p.595-599
Hauptverfasser:	Otoom, Sameer A., Hasan, Zuheir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Biological and medical sciences Brain slice CA1 Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - drug effects Hippocampus - physiology Male Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Neuropharmacology Pharmacology. Drug treatments Propofol Propofol - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Spontaneous and evoked bursting Veratridine Veratridine - pharmacology
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