Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: A comparison of selective and combined endothelin receptor blockade

Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade. We conducted a r...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2004-03, Vol.109 (9), p.1186-1193
Hauptverfasser:	GODDARD, Jane, JOHNSTON, Neil R, HAND, Malcolm F, CUMMING, Allan D, RABELINK, Ton J, RANKIN, Andrew J, WEBB, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive Agents - blood Antihypertensive Agents - therapeutic use Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cross-Over Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Double-Blind Method Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists Endothelin-1 - blood Hemodynamics - drug effects Humans Hypertension, Renal - drug therapy Hypertension, Renal - metabolism Hypertension, Renal - physiopathology Kidney - physiopathology Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - physiopathology Male Medical sciences Middle Aged Oligopeptides - therapeutic use Peptides, Cyclic - blood Peptides, Cyclic - therapeutic use Piperidines - therapeutic use Proteinuria - diagnosis Renal Circulation - drug effects Sodium - urine
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