Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites

Previously we reported that linoleic acid (LA), but not oleic acid, caused a marked increase in the secretion of IL-8 by Crohn's human intestinal smooth muscle (HISM) cells. Antioxidants inhibited this response, implicating a role for oxidative stress and NF-kappaB, a transcription factor for I...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2004-04, Vol.286 (4), p.G528-G537
Hauptverfasser:	Alzoghaibi, Mohammad A, Walsh, Scott W, Willey, Amy, Yager, Dorne R, Fowler, 3rd, Alpha A, Graham, Martin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid - metabolism Blotting, Western Cells, Cultured Crohn Disease - metabolism Cyclooxygenase Inhibitors - pharmacology Genes, Reporter Humans Indomethacin - pharmacology Interleukin-8 - biosynthesis Intestines - drug effects Intestines - metabolism Leukotriene B4 - biosynthesis Linoleic Acid - pharmacology Luciferases - genetics Muscle, Smooth - drug effects Muscle, Smooth - metabolism NF-kappa B - metabolism Oxidative Stress - physiology Receptors, Thromboxane - metabolism RNA, Messenger - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!