Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides

In this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-1 1–21) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The acti...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-03, Vol.14 (6), p.1399-1402
Hauptverfasser:	Anderson, Meagan E., Yakovleva, Tatyana, Hu, Yongbo, Siahaan, Teruna J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Cell Adhesion - physiology Cell Line, Tumor Dose-Response Relationship, Drug Drug Design Epithelial Cells - physiology Humans Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Lymphocyte Function-Associated Antigen-1 - genetics Lymphocyte Function-Associated Antigen-1 - metabolism Peptides, Cyclic - chemical synthesis Peptides, Cyclic - genetics Peptides, Cyclic - metabolism T-Lymphocytes - physiology
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