Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonist

Platelet activation and thrombus formation play a critical role in the onset of acute coronary syndromes. Thromboxane A2 (TxA2) is among the different chemical modulators released by activated platelets. TxA2 is considered one of the most powerful agonists for platelet activation. In addition, TxA2...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2004-03, Vol.2 (3), p.492-498
Hauptverfasser:	Osende, J. I., Shimbo, D., Fuster, V., Dubar, M., Badimon, J. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antithrombotic Disease Models, Animal Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Platelet Aggregation Inhibitors - pharmacology Receptors, Thromboxane - antagonists & inhibitors Sulfonamides - pharmacology Swine Tetrahydronaphthalenes - pharmacology thrombosis Thrombosis - prevention & control thromboxane A2 TP‐receptor
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