Sequential Functionalization of Pyrazole 1-Oxides via Regioselective Metalation:  Synthesis of 3,4,5-Trisubstituted 1-Hydroxypyrazoles

A range of 3,5-diarylated and 3,4,5-triarylated 2-(4-methoxybenzyl)pyrazole 1-oxides have been prepared by regioselective deprotonation at C-5 or bromine−magnesium exchange at C-3 or C-4 followed by transmetalation with ZnCl2 and palladium(0)-catalyzed cross-coupling. Furthermore, the metalated pyra...

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Veröffentlicht in:	Journal of organic chemistry 2002-05, Vol.67 (11), p.3904-3907
Hauptverfasser:	Paulson, Anna Sif, Eskildsen, Jørgen, Vedsø, Per, Begtrup, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Magnesium - chemistry Metals - chemistry Organic chemistry Oxides - chemical synthesis Palladium - chemistry Preparations and properties Pyrazoles - chemical synthesis Substrate Specificity Zinc - chemistry
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