Long‐term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides

We report here on 2 patients who received adjuvant vaccination with an HLA‐A2– or HLA‐A24–restricted tyrosinase peptide, respectively, and GM‐CSF for frequently relapsing stage IV melanoma. Following resection of metastases and irradiation of brain metastases in 1 patient, both patients were without...

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Veröffentlicht in:	International journal of cancer 2002-05, Vol.99 (3), p.403-408
Hauptverfasser:	Scheibenbogen, Carmen, Nagorsen, Dirk, Seliger, Barbara, Schmittel, Alexander, Letsch, Anne, Bauer, Sandra, Max, Nicole, Bock, Michaela, Atkins, Derek, Thiel, Eckhard, Keilholz, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	adjuvant Antineoplastic agents Biological and medical sciences Brain Neoplasms - prevention & control Brain Neoplasms - secondary Cancer Vaccines CD3 Complex - biosynthesis CD8 Antigens - biosynthesis Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Disease-Free Survival ELISPOT assay Epitopes Flow Cytometry Humans Immunohistochemistry Interferon-gamma - biosynthesis Interferon-gamma - metabolism Medical sciences Melanoma - diagnosis Melanoma - pathology Melanoma - prevention & control Monophenol Monooxygenase - therapeutic use Neoplasm Metastasis peptide Peptides - chemistry Peptides - therapeutic use Pharmacology. Drug treatments Polymerase Chain Reaction Recurrence RNA, Messenger - metabolism T-Lymphocytes - metabolism Time Factors tyrosinase vaccination
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