Megakaryocyte‐Osteoblast Interaction Revealed in Mice Deficient in Transcription Factors GATA‐1 and NF‐E2

Mice deficient in GATA‐1 or NF‐E2 have a 200–300% increase in bone volume and formation parameters. Osteoblasts and osteoclasts generated in vitro from mutant and control animals were similar in number and function. Osteoblast proliferation increased up to 6‐fold when cultured with megakaryocytes. A...

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Veröffentlicht in:	Journal of bone and mineral research 2004-04, Vol.19 (4), p.652-660
Hauptverfasser:	Kacena, Melissa A, Shivdasani, Ramesh A, Wilson, Kimberly, Xi, Yougen, Troiano, Nancy, Nazarian, Ara, Gundberg, Caren M, Bouxsein, Mary L, Lorenzo, Joseph A, Horowitz, Mark C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - biosynthesis anabolic Animals Biological and medical sciences Bone Density - genetics Bone Development - genetics Bone Development - physiology bone phenotype Cell Communication - genetics Cell Communication - physiology Cell Differentiation - genetics Cell Differentiation - physiology Cell Division - genetics Cell Division - physiology Cells, Cultured DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Erythroid-Specific DNA-Binding Factors Femur - diagnostic imaging Femur - physiopathology Fundamental and applied biological sciences. Psychology GATA1 Transcription Factor Megakaryocytes - cytology Megakaryocytes - physiology megakaryocytosis Mice Mice, Knockout NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit Osteoblasts - cytology Osteoblasts - physiology Osteocalcin - biosynthesis Osteoclasts - cytology Osteoclasts - physiology proliferation Radiography Skeleton and joints thrombocytopenia Tibia - physiopathology Tibia - ultrastructure Transcription Factors - deficiency Transcription Factors - genetics Vertebrates: osteoarticular system, musculoskeletal system
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