A role for niches in the development of a multiplicity of dendritic cell subsets
Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis....
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| Veröffentlicht in: | Experimental Hematology 2004-03, Vol.32 (3), p.235-243 |
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| creator | Despars, Geneviève O'Neill, Helen C |
| description | Although most studies on murine dendritic cell (DC) differentiation concentrate on the nature of the DC precursor population and the lineage relationship between DC and other hematopoietic cell types, very little research addresses the nature of the microenvironments necessary for DC hematopoiesis. Evidence supporting a major contribution of niches in DC differentiation within hematopoietic tissues is reviewed. A model is presented that identifies a potential role for multiple hematopoietic niches in DC differentiation. It is proposed that multiple DC subsets develop from one or a small number of DC progenitor types that lodge in various niches within different tissue sites. Implications of a niche-mediated model for differentiation of DC precursors are discussed in the context of both physiological and pathological situations. |
| doi_str_mv | 10.1016/j.exphem.2003.12.004 |
| format | Article |
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| ispartof | Experimental Hematology, 2004-03, Vol.32 (3), p.235-243 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Bone Marrow Cells - cytology Cell Differentiation Cytokines - physiology Dendritic Cells - classification Dendritic Cells - cytology Dendritic Cells - immunology Hematopoiesis - physiology Mice Models, Biological Organ Specificity Radiation Chimera Skin - cytology Stem Cells - cytology Thymus Gland - cytology Transcription Factors - physiology |
| title | A role for niches in the development of a multiplicity of dendritic cell subsets |
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