Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature
Background: Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC. Methods: We describe the clinicopathologic...
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| Veröffentlicht in: | Journal of cutaneous pathology 2004-04, Vol.31 (4), p.341-345 |
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| container_title | Journal of cutaneous pathology |
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| creator | Salamanca, J. Benito, A. García‐Peñalver, C. Azorín, D. Ballestín, C. Rodríguez‐Peralto, J. L. |
| description | Background: Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC.
Methods: We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Results: Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
Conclusions: As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease. |
| doi_str_mv | 10.1111/j.0303-6987.2004.0184.x |
| format | Article |
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Methods: We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Results: Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
Conclusions: As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease.</description><identifier>ISSN: 0303-6987</identifier><identifier>EISSN: 1600-0560</identifier><identifier>DOI: 10.1111/j.0303-6987.2004.0184.x</identifier><identifier>PMID: 15005693</identifier><identifier>CODEN: JCUPBN</identifier><language>eng</language><publisher>Oxford, UK; Malden , USA: Munksgaard International Publishers</publisher><subject>Aged ; Biological and medical sciences ; Biomarkers, Tumor ; Carcinoma in Situ - metabolism ; Carcinoma in Situ - pathology ; Carcinoma, Transitional Cell - metabolism ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - surgery ; Dermatology ; Humans ; Immunoenzyme Techniques ; Male ; Medical sciences ; Neoplasm Recurrence, Local ; Neoplasms, Multiple Primary ; Paget Disease, Extramammary - metabolism ; Paget Disease, Extramammary - pathology ; Penile Neoplasms - metabolism ; Penile Neoplasms - pathology ; Skin involvement in other diseases. Miscellaneous. General aspects ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery</subject><ispartof>Journal of cutaneous pathology, 2004-04, Vol.31 (4), p.341-345</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3914-b80bbd5859aebe9419f12437e1c956cd173d01f73c017e13987ef56769e2568c3</citedby><cites>FETCH-LOGICAL-c3914-b80bbd5859aebe9419f12437e1c956cd173d01f73c017e13987ef56769e2568c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.0303-6987.2004.0184.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.0303-6987.2004.0184.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15579751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15005693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salamanca, J.</creatorcontrib><creatorcontrib>Benito, A.</creatorcontrib><creatorcontrib>García‐Peñalver, C.</creatorcontrib><creatorcontrib>Azorín, D.</creatorcontrib><creatorcontrib>Ballestín, C.</creatorcontrib><creatorcontrib>Rodríguez‐Peralto, J. L.</creatorcontrib><title>Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature</title><title>Journal of cutaneous pathology</title><addtitle>J Cutan Pathol</addtitle><description>Background: Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC.
Methods: We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Results: Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
Conclusions: As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma, Transitional Cell - metabolism</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Dermatology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasms, Multiple Primary</subject><subject>Paget Disease, Extramammary - metabolism</subject><subject>Paget Disease, Extramammary - pathology</subject><subject>Penile Neoplasms - metabolism</subject><subject>Penile Neoplasms - pathology</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><issn>0303-6987</issn><issn>1600-0560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd9uFCEUxomxsWv1FZQb9WrGwzLAjL0yG_80aWIv7DVh4ExlMzuswLrtS_jMMu629VIugJzz-zjh-wh5zaBmZb1f18CBV7JrVb0EaGpgbVPfPiELJgEqEBKeksUDc0qep7QGYLKV4hk5ZQIK0vEF-X1lbjC_S9T5hCYhDQPNP5DejGZKdIuTTzShDZMz8Y7mQHMsDZ99mMxILY5lM9H6KWzMvbYfjXMYP1BDI25DzH8b-1DIhImayZX6L4_7e8HoM0aTdxFfkJPBjAlfHs8zcv350_fV1-ry25eL1cfLyvKONVXfQt870YrOYI9dw7qBLRuukNlOSOuY4g7YoLgFVoq8WICDkEp2uBSytfyMvD28u43h5w5T1huf5t-YCcMuacUUg0ZAAdUBtDGkFHHQ2-g3xQvNQM9R6LWebdazzXqOQs9R6NuifHUcses36B51R-8L8OYImGTNOBRjrU__cEJ1SrDCnR-4vR_x7n_n69X1VbnwP9flpQU</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Salamanca, J.</creator><creator>Benito, A.</creator><creator>García‐Peñalver, C.</creator><creator>Azorín, D.</creator><creator>Ballestín, C.</creator><creator>Rodríguez‐Peralto, J. L.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature</title><author>Salamanca, J. ; Benito, A. ; García‐Peñalver, C. ; Azorín, D. ; Ballestín, C. ; Rodríguez‐Peralto, J. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3914-b80bbd5859aebe9419f12437e1c956cd173d01f73c017e13987ef56769e2568c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma, Transitional Cell - metabolism</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Dermatology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasms, Multiple Primary</topic><topic>Paget Disease, Extramammary - metabolism</topic><topic>Paget Disease, Extramammary - pathology</topic><topic>Penile Neoplasms - metabolism</topic><topic>Penile Neoplasms - pathology</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salamanca, J.</creatorcontrib><creatorcontrib>Benito, A.</creatorcontrib><creatorcontrib>García‐Peñalver, C.</creatorcontrib><creatorcontrib>Azorín, D.</creatorcontrib><creatorcontrib>Ballestín, C.</creatorcontrib><creatorcontrib>Rodríguez‐Peralto, J. L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salamanca, J.</au><au>Benito, A.</au><au>García‐Peñalver, C.</au><au>Azorín, D.</au><au>Ballestín, C.</au><au>Rodríguez‐Peralto, J. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>2004-04</date><risdate>2004</risdate><volume>31</volume><issue>4</issue><spage>341</spage><epage>345</epage><pages>341-345</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>Background: Extramammary Paget's disease of the glans penis secondary to transitional cell carcinoma (TCC) of the bladder is rare, with only a few cases reported in the literature. We report two new cases, one detected before diagnosing bladder TCC.
Methods: We describe the clinicopathologic features of two patients with intraepithelial spread of glans TCC and the histochemical and immunohistochemical features of the neoplasm.
Results: Light microscopy detected intraepithelial proliferation of neoplastic, large, pale cells located predominantly in the basal and parabasal layers of the epithelium. The pagetoid cells showed positive cytoplasmic staining for mucosubstances and immunoreactivity for CK20. The previously reported cases are reviewed and the differential diagnosis is discussed.
Conclusions: As many benign and malignant glans lesions may be clinically similar, histologic study is necessary to correctly diagnose primary lesions and promptly detect underlying asymptomatic visceral malignancies initially presenting as Paget's disease.</abstract><cop>Oxford, UK; Malden , USA</cop><pub>Munksgaard International Publishers</pub><pmid>15005693</pmid><doi>10.1111/j.0303-6987.2004.0184.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Biomarkers, Tumor Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Dermatology Humans Immunoenzyme Techniques Male Medical sciences Neoplasm Recurrence, Local Neoplasms, Multiple Primary Paget Disease, Extramammary - metabolism Paget Disease, Extramammary - pathology Penile Neoplasms - metabolism Penile Neoplasms - pathology Skin involvement in other diseases. Miscellaneous. General aspects Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery |
| title | Paget's disease of the glans penis secondary to transitional cell carcinoma of the bladder: a report of two cases and review of the literature |
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