Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium
Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This stud...
Gespeichert in:
| Veröffentlicht in: | Japanese Heart Journal 2002, Vol.43(2), pp.167-181 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 2 |
| container_start_page | 167 |
| container_title | Japanese Heart Journal |
| container_volume | 43 |
| creator | Shiroshita, Akiko Mitamura, Hideo Shinagawa, Kaori Sato, Toshiaki Kurita, Yasuo Kanki, Hideaki Takatsuki, Seiji Hara, Motoki Ogawa, Satoshi |
| description | Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This study was designed to clarify the nature of the development and recovery of electrical remodeling in relation to AF inducibility in dogs subjected to rapid atrial pacing. Eleven dogs underwent rapid atrial pacing (400/min) for 28 days. The electrophysiological study was performed on the day just prior to the commencement of pacing, on days 2, 7, 14, and 28 of rapid pacing, as well as 1 and 7 days after the cessation of pacing. In response to rapid atrial pacing, atrial effective refractory period (ERP), conduction velocity and wavelength decreased significantly (p |
| doi_str_mv | 10.1536/jhj.43.167 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71709543</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71709543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-4c48f5bd6b8ab92c56917dcc1317f5e5710ef7b18f195eafd29363a6a9abd8243</originalsourceid><addsrcrecordid>eNpFkE1v1DAYhC1ERZfChR-AcoEDUhY7_khyQtW20EqVQKhI3KI39puNV4m92AnSHvnn9XZDe7Glmccz8hDyjtE1k1x93vW7teBrpsoXZMW4qHJV8t8vyYrSguWiUtU5eR3jjlKmioq_IuesoIWsqViRf1c2ah8MuCm7x3HvAwzZpge3xZhZl10PqKfg9_0hWj_4rdXJ_5EEDJNNiJmDddsFezR_4ugNDkcVnMlup5gk7f9iOBwDpx6zDTjrMLtML-bxDTnrYIj4drkvyK-v1_ebm_zu-7fbzeVdrmWtplxoUXWyNaqtoK0LLVXNSqM146zsJMqSUezKllUdqyVCZ4qaKw4KamhNVQh-QT6ecvfB_5kxTs2Yvo7DAA79HJuSlbSWgifw0wnUwccYsGv2wY4QDg2jzXHwJg3eCN6kwRP8fkmd2xHNM7osnIAPCwAxzdMFcNrGZ44rptRj65cTt4sTbPEJgLSzHvB_Z3E6UvWTo3sIDTr-AHqpokg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71709543</pqid></control><display><type>article</type><title>Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Shiroshita, Akiko ; Mitamura, Hideo ; Shinagawa, Kaori ; Sato, Toshiaki ; Kurita, Yasuo ; Kanki, Hideaki ; Takatsuki, Seiji ; Hara, Motoki ; Ogawa, Satoshi</creator><creatorcontrib>Shiroshita, Akiko ; Mitamura, Hideo ; Shinagawa, Kaori ; Sato, Toshiaki ; Kurita, Yasuo ; Kanki, Hideaki ; Takatsuki, Seiji ; Hara, Motoki ; Ogawa, Satoshi</creatorcontrib><description>Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This study was designed to clarify the nature of the development and recovery of electrical remodeling in relation to AF inducibility in dogs subjected to rapid atrial pacing. Eleven dogs underwent rapid atrial pacing (400/min) for 28 days. The electrophysiological study was performed on the day just prior to the commencement of pacing, on days 2, 7, 14, and 28 of rapid pacing, as well as 1 and 7 days after the cessation of pacing. In response to rapid atrial pacing, atrial effective refractory period (ERP), conduction velocity and wavelength decreased significantly (p<0.05). ERP had shortened significantly and rapidly within 2 days of pacing, while conduction velocity decreased more gradually. During the recovery, ERP returned to almost baseline levels within a day, whereas conduction velocity returned to baseline by day 7. Sustained AF became inducible in 37% of the dogs from 7 days of pacing until 1 day after the cessation, when wavelength fell below 8.7 cm. In conclusion, rapid atrial excitation causes a progressive but discordant temporal pattern of a decrease in ERP and conduction velocity. The resultant shortening of the wavelength determines the inducibility and maintenance of AF. The electrophysiological changes produced by one month of rapid atrial pacing can be fully reversed within a week, although in a discordant temporal pattern.</description><identifier>ISSN: 0021-4868</identifier><identifier>EISSN: 1348-673X</identifier><identifier>DOI: 10.1536/jhj.43.167</identifier><identifier>PMID: 12025904</identifier><identifier>CODEN: JHEJAR</identifier><language>eng</language><publisher>Tokyo: International Heart Journal Association</publisher><subject>Animals ; Atrial fibrillation ; Atrial Fibrillation - physiopathology ; Atrial Function ; Biological and medical sciences ; Cardiac dysrhythmias ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Conduction characteristics ; Dogs ; Electric Stimulation ; Electrophysiology ; Female ; Heart ; Heart Conduction System - physiopathology ; Male ; Medical sciences ; Rapid atrial pacing ; Reversibility</subject><ispartof>Japanese Heart Journal, 2002, Vol.43(2), pp.167-181</ispartof><rights>2002 by the Japanese Heart Journal</rights><rights>2002 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-4c48f5bd6b8ab92c56917dcc1317f5e5710ef7b18f195eafd29363a6a9abd8243</citedby><cites>FETCH-LOGICAL-c596t-4c48f5bd6b8ab92c56917dcc1317f5e5710ef7b18f195eafd29363a6a9abd8243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13616643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12025904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shiroshita, Akiko</creatorcontrib><creatorcontrib>Mitamura, Hideo</creatorcontrib><creatorcontrib>Shinagawa, Kaori</creatorcontrib><creatorcontrib>Sato, Toshiaki</creatorcontrib><creatorcontrib>Kurita, Yasuo</creatorcontrib><creatorcontrib>Kanki, Hideaki</creatorcontrib><creatorcontrib>Takatsuki, Seiji</creatorcontrib><creatorcontrib>Hara, Motoki</creatorcontrib><creatorcontrib>Ogawa, Satoshi</creatorcontrib><title>Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium</title><title>Japanese Heart Journal</title><addtitle>Jpn Heart J</addtitle><description>Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This study was designed to clarify the nature of the development and recovery of electrical remodeling in relation to AF inducibility in dogs subjected to rapid atrial pacing. Eleven dogs underwent rapid atrial pacing (400/min) for 28 days. The electrophysiological study was performed on the day just prior to the commencement of pacing, on days 2, 7, 14, and 28 of rapid pacing, as well as 1 and 7 days after the cessation of pacing. In response to rapid atrial pacing, atrial effective refractory period (ERP), conduction velocity and wavelength decreased significantly (p<0.05). ERP had shortened significantly and rapidly within 2 days of pacing, while conduction velocity decreased more gradually. During the recovery, ERP returned to almost baseline levels within a day, whereas conduction velocity returned to baseline by day 7. Sustained AF became inducible in 37% of the dogs from 7 days of pacing until 1 day after the cessation, when wavelength fell below 8.7 cm. In conclusion, rapid atrial excitation causes a progressive but discordant temporal pattern of a decrease in ERP and conduction velocity. The resultant shortening of the wavelength determines the inducibility and maintenance of AF. The electrophysiological changes produced by one month of rapid atrial pacing can be fully reversed within a week, although in a discordant temporal pattern.</description><subject>Animals</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Function</subject><subject>Biological and medical sciences</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Conduction characteristics</subject><subject>Dogs</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Conduction System - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rapid atrial pacing</subject><subject>Reversibility</subject><issn>0021-4868</issn><issn>1348-673X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAYhC1ERZfChR-AcoEDUhY7_khyQtW20EqVQKhI3KI39puNV4m92AnSHvnn9XZDe7Glmccz8hDyjtE1k1x93vW7teBrpsoXZMW4qHJV8t8vyYrSguWiUtU5eR3jjlKmioq_IuesoIWsqViRf1c2ah8MuCm7x3HvAwzZpge3xZhZl10PqKfg9_0hWj_4rdXJ_5EEDJNNiJmDddsFezR_4ugNDkcVnMlup5gk7f9iOBwDpx6zDTjrMLtML-bxDTnrYIj4drkvyK-v1_ebm_zu-7fbzeVdrmWtplxoUXWyNaqtoK0LLVXNSqM146zsJMqSUezKllUdqyVCZ4qaKw4KamhNVQh-QT6ecvfB_5kxTs2Yvo7DAA79HJuSlbSWgifw0wnUwccYsGv2wY4QDg2jzXHwJg3eCN6kwRP8fkmd2xHNM7osnIAPCwAxzdMFcNrGZ44rptRj65cTt4sTbPEJgLSzHvB_Z3E6UvWTo3sIDTr-AHqpokg</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Shiroshita, Akiko</creator><creator>Mitamura, Hideo</creator><creator>Shinagawa, Kaori</creator><creator>Sato, Toshiaki</creator><creator>Kurita, Yasuo</creator><creator>Kanki, Hideaki</creator><creator>Takatsuki, Seiji</creator><creator>Hara, Motoki</creator><creator>Ogawa, Satoshi</creator><general>International Heart Journal Association</general><general>Japanese Heart Journal Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium</title><author>Shiroshita, Akiko ; Mitamura, Hideo ; Shinagawa, Kaori ; Sato, Toshiaki ; Kurita, Yasuo ; Kanki, Hideaki ; Takatsuki, Seiji ; Hara, Motoki ; Ogawa, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-4c48f5bd6b8ab92c56917dcc1317f5e5710ef7b18f195eafd29363a6a9abd8243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Function</topic><topic>Biological and medical sciences</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Conduction characteristics</topic><topic>Dogs</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Conduction System - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rapid atrial pacing</topic><topic>Reversibility</topic><toplevel>online_resources</toplevel><creatorcontrib>Shiroshita, Akiko</creatorcontrib><creatorcontrib>Mitamura, Hideo</creatorcontrib><creatorcontrib>Shinagawa, Kaori</creatorcontrib><creatorcontrib>Sato, Toshiaki</creatorcontrib><creatorcontrib>Kurita, Yasuo</creatorcontrib><creatorcontrib>Kanki, Hideaki</creatorcontrib><creatorcontrib>Takatsuki, Seiji</creatorcontrib><creatorcontrib>Hara, Motoki</creatorcontrib><creatorcontrib>Ogawa, Satoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shiroshita, Akiko</au><au>Mitamura, Hideo</au><au>Shinagawa, Kaori</au><au>Sato, Toshiaki</au><au>Kurita, Yasuo</au><au>Kanki, Hideaki</au><au>Takatsuki, Seiji</au><au>Hara, Motoki</au><au>Ogawa, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium</atitle><jtitle>Japanese Heart Journal</jtitle><addtitle>Jpn Heart J</addtitle><date>2002</date><risdate>2002</risdate><volume>43</volume><issue>2</issue><spage>167</spage><epage>181</epage><pages>167-181</pages><issn>0021-4868</issn><eissn>1348-673X</eissn><coden>JHEJAR</coden><abstract>Prolonged rapid atrial excitation gives rise to atrial electrical remodeling, which perpetuates atrial fibrillation (AF). However, there has been controversy regarding the nature of temporal changes in conduction characteristics during the development and recovery of electrical remodeling. This study was designed to clarify the nature of the development and recovery of electrical remodeling in relation to AF inducibility in dogs subjected to rapid atrial pacing. Eleven dogs underwent rapid atrial pacing (400/min) for 28 days. The electrophysiological study was performed on the day just prior to the commencement of pacing, on days 2, 7, 14, and 28 of rapid pacing, as well as 1 and 7 days after the cessation of pacing. In response to rapid atrial pacing, atrial effective refractory period (ERP), conduction velocity and wavelength decreased significantly (p<0.05). ERP had shortened significantly and rapidly within 2 days of pacing, while conduction velocity decreased more gradually. During the recovery, ERP returned to almost baseline levels within a day, whereas conduction velocity returned to baseline by day 7. Sustained AF became inducible in 37% of the dogs from 7 days of pacing until 1 day after the cessation, when wavelength fell below 8.7 cm. In conclusion, rapid atrial excitation causes a progressive but discordant temporal pattern of a decrease in ERP and conduction velocity. The resultant shortening of the wavelength determines the inducibility and maintenance of AF. The electrophysiological changes produced by one month of rapid atrial pacing can be fully reversed within a week, although in a discordant temporal pattern.</abstract><cop>Tokyo</cop><pub>International Heart Journal Association</pub><pmid>12025904</pmid><doi>10.1536/jhj.43.167</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-4868 |
| ispartof | Japanese Heart Journal, 2002, Vol.43(2), pp.167-181 |
| issn | 0021-4868 1348-673X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71709543 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Atrial fibrillation Atrial Fibrillation - physiopathology Atrial Function Biological and medical sciences Cardiac dysrhythmias Cardiac Pacing, Artificial Cardiology. Vascular system Conduction characteristics Dogs Electric Stimulation Electrophysiology Female Heart Heart Conduction System - physiopathology Male Medical sciences Rapid atrial pacing Reversibility |
| title | Discordant Temporal Changes in Electrophysiological Properties during Electrical Remodeling and Its Recovery in the Canine Atrium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T22%3A07%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discordant%20Temporal%20Changes%20in%20Electrophysiological%20Properties%20during%20Electrical%20Remodeling%20and%20Its%20Recovery%20in%20the%20Canine%20Atrium&rft.jtitle=Japanese%20Heart%20Journal&rft.au=Shiroshita,%20Akiko&rft.date=2002&rft.volume=43&rft.issue=2&rft.spage=167&rft.epage=181&rft.pages=167-181&rft.issn=0021-4868&rft.eissn=1348-673X&rft.coden=JHEJAR&rft_id=info:doi/10.1536/jhj.43.167&rft_dat=%3Cproquest_cross%3E71709543%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71709543&rft_id=info:pmid/12025904&rfr_iscdi=true |