Synthesis of Antisense Oligonucleotide−Peptide Conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells

A simple procedure for the preparation of oligonucleotide−peptide conjugate was developed. p-Hydroxy-benzoic acid was used as a linker for the connection of the fragments of peptide and oligonucleotide. It was found that such formed linkage was stable under the conditions of conjugate synthesis. The...

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Veröffentlicht in:	Bioconjugate chemistry 2002-05, Vol.13 (3), p.525-529
Hauptverfasser:	Chen, Chang-Po, Li, Xiao-Xu, Zhang, Liang-Ren, Min, Ji-Mei, Chan, Judy Yuet-Wah, Fung, Kwok-Pui, Wang, Sheng-Qi, Zhang, Li−He
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense Blotting, Northern Blotting, Western Cell Division - drug effects Cell membranes Cross-Linking Reagents - chemistry Dose-Response Relationship, Drug Female Glucose Transporter Type 1 Humans Monosaccharide Transport Proteins - genetics Oligonucleotides, Antisense - chemical synthesis Oligonucleotides, Antisense - pharmacology Parabens - chemistry Peptides - chemical synthesis Peptides - pharmacology Q1 RNA, Messenger - metabolism Thionucleotides Transfection Tumor Cells, Cultured - drug effects
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