Revisiting the Mechanism of P450 Enzymes with the Radical Clocks Norcarane and Spiro[2,5]octane

Norcarane (1) and spiro[2.5]octane (2) yield different product distributions depending on whether they are oxidized via concerted, radical, or cationic mechanisms. For this reason, these two probes were used to investigate the mechanisms of hydrocarbon hydroxylation by two mammalian and two bacteria...

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Veröffentlicht in:Journal of the American Chemical Society 2002-05, Vol.124 (21), p.6020-6027
Hauptverfasser: Auclair, Karine, Hu, Zhengbo, Little, Dorothy M, Ortiz de Montellano, Paul R, Groves, John T
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Sprache:eng
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