Coxsackieviral-mediated diabetes: induction requires antigen-presenting cells and is accompanied by phagocytosis of beta cells

Epidemiological studies have associated coxsackie B virus (CBV) with the development of insulin-dependent diabetes mellitus (IDDM) in humans. Infections of genetically susceptible mice with CBV strain 4 (CB4) induce autoimmune diabetes. Herein, we demonstrate that in mice, CB4 infection of insulin-p...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2004-02, Vol.110 (2), p.134-144
Hauptverfasser:	Horwitz, Marc S, Ilic, Alex, Fine, Cody, Balasa, Balaji, Sarvetnick, Nora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-presenting cells Antigen-Presenting Cells - immunology Antigen-Presenting Cells - pathology Antigen-Presenting Cells - virology Biological and medical sciences Cell Division - immunology Coxsackievirus Coxsackievirus Infections - immunology Coxsackievirus Infections - pathology Coxsackievirus Infections - virology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - virology Enterovirus B, Human - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocytochemistry Human coxsackievirus Immunopathology Insulin - immunology Insulin - metabolism Insulin-dependent diabetes mellitus Islets of Langerhans - immunology Islets of Langerhans - pathology Islets of Langerhans - ultrastructure Islets of Langerhans - virology Medical sciences Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Microscopy, Confocal Microscopy, Electron Phagocytosis - immunology T lymphocytes
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