Associations between Human Leukocyte Antigen Homozygosity and Antibody Levels to Measles Vaccine
The association between human leukocyte antigen (HLA) homozygosity and measles antibody levels was assessed in a volunteer group of 242 children. Serum samples were tested for measles IgG antibodies, class I and class II HLA alleles were typed, and associations were examined between HLA homozygosity...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-06, Vol.185 (11), p.1545-1549 |
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| container_title | The Journal of infectious diseases |
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| creator | St. Sauver, Jennifer L. Ovsyannikova, Inna G. Jacobson, Robert M. Jacobsen, Steven J. Vierkant, Robert A. Schaid, Daniel J. Pankratz, V. Shane Green, Erin M. Poland, Gregory A. |
| description | The association between human leukocyte antigen (HLA) homozygosity and measles antibody levels was assessed in a volunteer group of 242 children. Serum samples were tested for measles IgG antibodies, class I and class II HLA alleles were typed, and associations were examined between HLA homozygosity and antibody levels. Children who were homozygous for at least 1 locus were twice as likely to be seronegative (odds ratio, 1.97; 95% confidence interval, 1.08–3.61). Children who were homozygous at ⩾1 loci were increasingly likely to be seronegative (χ2 test for trend; P = .02). When serum antibody levels were examined as continuous variables, children who were homozygous at certain loci tended to have lower mean antibody levels. These results suggest that lack of HLA diversity may limit the range of peptides that can be presented to antibody-producing cells, potentially resulting in a decreased immune response to viral infections. |
| doi_str_mv | 10.1086/340573 |
| format | Article |
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Shane</creatorcontrib><creatorcontrib>Green, Erin M.</creatorcontrib><creatorcontrib>Poland, Gregory A.</creatorcontrib><title>Associations between Human Leukocyte Antigen Homozygosity and Antibody Levels to Measles Vaccine</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>The association between human leukocyte antigen (HLA) homozygosity and measles antibody levels was assessed in a volunteer group of 242 children. Serum samples were tested for measles IgG antibodies, class I and class II HLA alleles were typed, and associations were examined between HLA homozygosity and antibody levels. Children who were homozygous for at least 1 locus were twice as likely to be seronegative (odds ratio, 1.97; 95% confidence interval, 1.08–3.61). Children who were homozygous at ⩾1 loci were increasingly likely to be seronegative (χ2 test for trend; P = .02). 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Genome</subject><subject>Genetic loci</subject><subject>Heterozygotes</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Histocompatibility Testing</subject><subject>HLA antigens</subject><subject>HLA Antigens - genetics</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunoglobulin G - blood</subject><subject>Major Articles</subject><subject>Measles</subject><subject>Measles Vaccine - immunology</subject><subject>Measles vaccines</subject><subject>Measles virus - immunology</subject><subject>Microbiology</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Vaccination</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d-L1DAQB_Agird36n-g1APvrZofTZM8Lsede7Ci4CniS0zT6dG9tlk76Wn96-3a5RYE8SmQ-TCTb4aQZ4y-ZlTnb0RGpRIPyIJJodI8Z-IhWVDKecq0MUfkGHFDKc1Erh6TI8YpF0qaBfm2RAy-drEOHSYFxB8AXbIaWtclaxhugx8jJMsu1je7-9CGX-NNwDqOievKP4UilONk76DBJIbkHThsAJPPzvu6gyfkUeUahKf784R8ury4Pl-l6_dvr86X69RnmsXUOXCFUozpQhWcc20AVF4CF5kpmGSlLJyspM4qyXWZ5yrnUzpNKdMlFKUXJ-Rs7rvtw_cBMNq2Rg9N4zoIA1rFFNVZrv4Lmc6kmd4xwdO_4CYMfTeFsJwLbbRW2aGb7wNiD5Xd9nXr-tEyanebsfNmJvhi320oWigPbL-KCbzaA4feNVXvOl_jwQlFDde7iS9nF4btv4c9n80GY-jvlaBMaKp30dK5XmOEn_d119_a6YeUtKsvX-3ltV59_ECNleI3SIa2sQ</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>St. Sauver, Jennifer L.</creator><creator>Ovsyannikova, Inna G.</creator><creator>Jacobson, Robert M.</creator><creator>Jacobsen, Steven J.</creator><creator>Vierkant, Robert A.</creator><creator>Schaid, Daniel J.</creator><creator>Pankratz, V. Shane</creator><creator>Green, Erin M.</creator><creator>Poland, Gregory A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Associations between Human Leukocyte Antigen Homozygosity and Antibody Levels to Measles Vaccine</title><author>St. Sauver, Jennifer L. ; Ovsyannikova, Inna G. ; Jacobson, Robert M. ; Jacobsen, Steven J. ; Vierkant, Robert A. ; Schaid, Daniel J. ; Pankratz, V. 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Genome</topic><topic>Genetic loci</topic><topic>Heterozygotes</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class II - genetics</topic><topic>Histocompatibility Testing</topic><topic>HLA antigens</topic><topic>HLA Antigens - genetics</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunoglobulin G - blood</topic><topic>Major Articles</topic><topic>Measles</topic><topic>Measles Vaccine - immunology</topic><topic>Measles vaccines</topic><topic>Measles virus - immunology</topic><topic>Microbiology</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Vaccination</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>St. Sauver, Jennifer L.</creatorcontrib><creatorcontrib>Ovsyannikova, Inna G.</creatorcontrib><creatorcontrib>Jacobson, Robert M.</creatorcontrib><creatorcontrib>Jacobsen, Steven J.</creatorcontrib><creatorcontrib>Vierkant, Robert A.</creatorcontrib><creatorcontrib>Schaid, Daniel J.</creatorcontrib><creatorcontrib>Pankratz, V. 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Shane</au><au>Green, Erin M.</au><au>Poland, Gregory A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between Human Leukocyte Antigen Homozygosity and Antibody Levels to Measles Vaccine</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>185</volume><issue>11</issue><spage>1545</spage><epage>1549</epage><pages>1545-1549</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The association between human leukocyte antigen (HLA) homozygosity and measles antibody levels was assessed in a volunteer group of 242 children. Serum samples were tested for measles IgG antibodies, class I and class II HLA alleles were typed, and associations were examined between HLA homozygosity and antibody levels. Children who were homozygous for at least 1 locus were twice as likely to be seronegative (odds ratio, 1.97; 95% confidence interval, 1.08–3.61). Children who were homozygous at ⩾1 loci were increasingly likely to be seronegative (χ2 test for trend; P = .02). When serum antibody levels were examined as continuous variables, children who were homozygous at certain loci tended to have lower mean antibody levels. These results suggest that lack of HLA diversity may limit the range of peptides that can be presented to antibody-producing cells, potentially resulting in a decreased immune response to viral infections.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12023759</pmid><doi>10.1086/340573</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Alleles Antibodies Antibodies, Viral - blood Biological and medical sciences Child Child, Preschool Fundamental and applied biological sciences. Psychology Genes. Genome Genetic loci Heterozygotes Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class II - genetics Histocompatibility Testing HLA antigens HLA Antigens - genetics Homozygote Humans Immune response Immunoglobulin G - blood Major Articles Measles Measles Vaccine - immunology Measles vaccines Measles virus - immunology Microbiology Molecular and cellular biology Molecular genetics Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Vaccination Virology Viruses |
| title | Associations between Human Leukocyte Antigen Homozygosity and Antibody Levels to Measles Vaccine |
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