Characterization of a De Novo Conversion in Human Complement C4 Gene Producing a C4B5-Like Protein

Complement C4 is a highly polymorphic protein essential for the activation of the classical complement pathway. Most of the allelic variation of C4 resides in the C4d region. Four polymorphic amino acid residues specify the isotype and an additional four specify the Rodgers and Chido determinants of...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-06, Vol.168 (11), p.5652-5658
Hauptverfasser:	Jaatinen, Taina, Eholuoto, Miia, Laitinen, Tarja, Lokki, Marja-Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Complement C4a - genetics Complement C4b - genetics Gene Conversion Haplotypes Humans Introns Major Histocompatibility Complex
Online-Zugang:	Volltext
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