Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon
To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites:...
Gespeichert in:
| Veröffentlicht in: | AIDS research and human retroviruses 2004, Vol.20 (1), p.105-109 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 109 |
|---|---|
| container_issue | 1 |
| container_start_page | 105 |
| container_title | AIDS research and human retroviruses |
| container_volume | 20 |
| creator | KONINGS, Frank A. J PING ZHONG NYAMBI, Phillipe N AGWARA, Moise AGYINGI, Lucy ZEKENG, Leopold ACHKAR, Jacqueline M EWANE, Leonard SAA, D AFANE ZE, Emmanuel KINGE, Thompson |
| description | To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas. |
| doi_str_mv | 10.1089/088922204322749558 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71707758</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19268364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c360t-9577c7f49fec4d2798a50e4f4e25e60be2062643aa7e24b0cf49601d987b89393</originalsourceid><addsrcrecordid>eNqF0MFKAzEQBuAgitbqC3iQXPS2Oskmm-SoRa0g6EG9Lmk6WyLdpCa7Bd_e1RYUPHgKDN_8E35CThhcMNDmErQ2nHMQJedKGCn1DhkxU7JCC5C7ZPQFikGYA3KY8xsADF7ukwMmATTjckSen1Ls0Gakbd_ZzseQqQ90ev9aMBpiKK5p7pL13-MGXefDgs5TvyiC9Wuka79c2gWmTGNDnW0xxRiOyF5jlxmPt--YvNzePE-mxcPj3f3k6qFwZQVdYaRSTjXCDLlizpXRVgKKRiCXWMEMOVS8EqW1CrmYgRtoBWxutJppU5pyTM43uasU33vMXd367HD4UcDY51oxBUpJ_S9khle6HE6NCd9Al2LOCZt6lXxr00fNoP4qvf5b-rB0uk3vZy3Of1a2LQ_gbAtsdnbZJBucz7-cEEpUqvwEhceH-Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19268364</pqid></control><display><type>article</type><title>Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon</title><source>Mary Ann Liebert Online Subscription</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>KONINGS, Frank A. J ; PING ZHONG ; NYAMBI, Phillipe N ; AGWARA, Moise ; AGYINGI, Lucy ; ZEKENG, Leopold ; ACHKAR, Jacqueline M ; EWANE, Leonard ; SAA, D ; AFANE ZE, Emmanuel ; KINGE, Thompson</creator><creatorcontrib>KONINGS, Frank A. J ; PING ZHONG ; NYAMBI, Phillipe N ; AGWARA, Moise ; AGYINGI, Lucy ; ZEKENG, Leopold ; ACHKAR, Jacqueline M ; EWANE, Leonard ; SAA, D ; AFANE ZE, Emmanuel ; KINGE, Thompson</creatorcontrib><description>To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/088922204322749558</identifier><identifier>PMID: 15008125</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Adolescent ; Adult ; Aged ; AIDS/HIV ; Anti-HIV Agents - pharmacology ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Cameroon - epidemiology ; Drug Resistance, Viral ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV Protease - genetics ; HIV Protease Inhibitors - pharmacology ; HIV Protease Inhibitors - therapeutic use ; HIV-1 - classification ; HIV-1 - drug effects ; HIV-1 - enzymology ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Sequence Data ; Mutation ; Rural Population ; Sequence Analysis, DNA ; Viral diseases ; Virology</subject><ispartof>AIDS research and human retroviruses, 2004, Vol.20 (1), p.105-109</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-9577c7f49fec4d2798a50e4f4e25e60be2062643aa7e24b0cf49601d987b89393</citedby><cites>FETCH-LOGICAL-c360t-9577c7f49fec4d2798a50e4f4e25e60be2062643aa7e24b0cf49601d987b89393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3042,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15447467$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15008125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KONINGS, Frank A. J</creatorcontrib><creatorcontrib>PING ZHONG</creatorcontrib><creatorcontrib>NYAMBI, Phillipe N</creatorcontrib><creatorcontrib>AGWARA, Moise</creatorcontrib><creatorcontrib>AGYINGI, Lucy</creatorcontrib><creatorcontrib>ZEKENG, Leopold</creatorcontrib><creatorcontrib>ACHKAR, Jacqueline M</creatorcontrib><creatorcontrib>EWANE, Leonard</creatorcontrib><creatorcontrib>SAA, D</creatorcontrib><creatorcontrib>AFANE ZE, Emmanuel</creatorcontrib><creatorcontrib>KINGE, Thompson</creatorcontrib><title>Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cameroon - epidemiology</subject><subject>Drug Resistance, Viral</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV Protease - genetics</subject><subject>HIV Protease Inhibitors - pharmacology</subject><subject>HIV Protease Inhibitors - therapeutic use</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - enzymology</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Rural Population</subject><subject>Sequence Analysis, DNA</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFKAzEQBuAgitbqC3iQXPS2Oskmm-SoRa0g6EG9Lmk6WyLdpCa7Bd_e1RYUPHgKDN_8E35CThhcMNDmErQ2nHMQJedKGCn1DhkxU7JCC5C7ZPQFikGYA3KY8xsADF7ukwMmATTjckSen1Ls0Gakbd_ZzseQqQ90ev9aMBpiKK5p7pL13-MGXefDgs5TvyiC9Wuka79c2gWmTGNDnW0xxRiOyF5jlxmPt--YvNzePE-mxcPj3f3k6qFwZQVdYaRSTjXCDLlizpXRVgKKRiCXWMEMOVS8EqW1CrmYgRtoBWxutJppU5pyTM43uasU33vMXd367HD4UcDY51oxBUpJ_S9khle6HE6NCd9Al2LOCZt6lXxr00fNoP4qvf5b-rB0uk3vZy3Of1a2LQ_gbAtsdnbZJBucz7-cEEpUqvwEhceH-Q</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>KONINGS, Frank A. J</creator><creator>PING ZHONG</creator><creator>NYAMBI, Phillipe N</creator><creator>AGWARA, Moise</creator><creator>AGYINGI, Lucy</creator><creator>ZEKENG, Leopold</creator><creator>ACHKAR, Jacqueline M</creator><creator>EWANE, Leonard</creator><creator>SAA, D</creator><creator>AFANE ZE, Emmanuel</creator><creator>KINGE, Thompson</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon</title><author>KONINGS, Frank A. J ; PING ZHONG ; NYAMBI, Phillipe N ; AGWARA, Moise ; AGYINGI, Lucy ; ZEKENG, Leopold ; ACHKAR, Jacqueline M ; EWANE, Leonard ; SAA, D ; AFANE ZE, Emmanuel ; KINGE, Thompson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-9577c7f49fec4d2798a50e4f4e25e60be2062643aa7e24b0cf49601d987b89393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cameroon - epidemiology</topic><topic>Drug Resistance, Viral</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV Protease - genetics</topic><topic>HIV Protease Inhibitors - pharmacology</topic><topic>HIV Protease Inhibitors - therapeutic use</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - enzymology</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Rural Population</topic><topic>Sequence Analysis, DNA</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KONINGS, Frank A. J</creatorcontrib><creatorcontrib>PING ZHONG</creatorcontrib><creatorcontrib>NYAMBI, Phillipe N</creatorcontrib><creatorcontrib>AGWARA, Moise</creatorcontrib><creatorcontrib>AGYINGI, Lucy</creatorcontrib><creatorcontrib>ZEKENG, Leopold</creatorcontrib><creatorcontrib>ACHKAR, Jacqueline M</creatorcontrib><creatorcontrib>EWANE, Leonard</creatorcontrib><creatorcontrib>SAA, D</creatorcontrib><creatorcontrib>AFANE ZE, Emmanuel</creatorcontrib><creatorcontrib>KINGE, Thompson</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONINGS, Frank A. J</au><au>PING ZHONG</au><au>NYAMBI, Phillipe N</au><au>AGWARA, Moise</au><au>AGYINGI, Lucy</au><au>ZEKENG, Leopold</au><au>ACHKAR, Jacqueline M</au><au>EWANE, Leonard</au><au>SAA, D</au><au>AFANE ZE, Emmanuel</au><au>KINGE, Thompson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2004</date><risdate>2004</risdate><volume>20</volume><issue>1</issue><spage>105</spage><epage>109</epage><pages>105-109</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>15008125</pmid><doi>10.1089/088922204322749558</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2004, Vol.20 (1), p.105-109 |
| issn | 0889-2229 1931-8405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71707758 |
| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged AIDS/HIV Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Biological and medical sciences Cameroon - epidemiology Drug Resistance, Viral Female Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - virology HIV Protease - genetics HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use HIV-1 - classification HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Sequence Data Mutation Rural Population Sequence Analysis, DNA Viral diseases Virology |
| title | Protease mutations in HIV-1 non-B strains infecting drug-naive villagers of cameroon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T00%3A39%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protease%20mutations%20in%20HIV-1%20non-B%20strains%20infecting%20drug-naive%20villagers%20of%20cameroon&rft.jtitle=AIDS%20research%20and%20human%20retroviruses&rft.au=KONINGS,%20Frank%20A.%20J&rft.date=2004&rft.volume=20&rft.issue=1&rft.spage=105&rft.epage=109&rft.pages=105-109&rft.issn=0889-2229&rft.eissn=1931-8405&rft.coden=ARHRE7&rft_id=info:doi/10.1089/088922204322749558&rft_dat=%3Cproquest_cross%3E19268364%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19268364&rft_id=info:pmid/15008125&rfr_iscdi=true |