Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism
A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol,...
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| Veröffentlicht in: | Journal of comparative pathology 2004-02, Vol.130 (2), p.209-215 |
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| container_title | Journal of comparative pathology |
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| creator | Meij, B.P. van der Vlugt-Meijer, R.H. van den Ingh, T.S.G.A.M. Rijnberk, A. |
| description | A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) to suppression by a low dose of dexamethasone, but also elevated plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). Pituitary imaging with dynamic contrast-enhanced computed tomography demonstrated an enlarged pituitary gland and an adenoma. The cat underwent trans-sphenoidal hypophysectomy after which the insulin resistance disappeared. On histopathological and immunocytochemical examination of the surgical specimen a double adenoma was found, consisting of a corticotroph adenoma and a somatotroph adenoma separated by unaffected pituitary tissue. |
| doi_str_mv | 10.1016/j.jcpa.2003.09.004 |
| format | Article |
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Further studies revealed not only resistance of plasma concentrations of cortisol, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) to suppression by a low dose of dexamethasone, but also elevated plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). Pituitary imaging with dynamic contrast-enhanced computed tomography demonstrated an enlarged pituitary gland and an adenoma. The cat underwent trans-sphenoidal hypophysectomy after which the insulin resistance disappeared. On histopathological and immunocytochemical examination of the surgical specimen a double adenoma was found, consisting of a corticotroph adenoma and a somatotroph adenoma separated by unaffected pituitary tissue.</description><identifier>ISSN: 0021-9975</identifier><identifier>EISSN: 1532-3129</identifier><identifier>DOI: 10.1016/j.jcpa.2003.09.004</identifier><identifier>PMID: 15003481</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>acromegaly ; Adenoma - complications ; Adenoma - pathology ; Adenoma - veterinary ; Adrenocorticotropic Hormone - blood ; Adrenocorticotropic Hormone - metabolism ; alpha-MSH - blood ; Animals ; cat ; Cat Diseases - pathology ; Cat Diseases - physiopathology ; Cats ; Cushing Syndrome - etiology ; Cushing Syndrome - veterinary ; Cushing's disease ; Diabetes Mellitus - etiology ; Diabetes Mellitus - veterinary ; double adenoma ; Growth Hormone - blood ; Growth Hormone - metabolism ; Hydrocortisone - blood ; hypophysectomy ; Insulin Resistance ; Insulin-Like Growth Factor I - analysis ; Male ; man ; pituitary ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - pathology ; Pituitary Neoplasms - veterinary ; tumour</subject><ispartof>Journal of comparative pathology, 2004-02, Vol.130 (2), p.209-215</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-2ba603d1becb48458ac51d167da284fd52218d952df038f148718b0e5e23a7ac3</citedby><cites>FETCH-LOGICAL-c352t-2ba603d1becb48458ac51d167da284fd52218d952df038f148718b0e5e23a7ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021997503001099$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15003481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meij, B.P.</creatorcontrib><creatorcontrib>van der Vlugt-Meijer, R.H.</creatorcontrib><creatorcontrib>van den Ingh, T.S.G.A.M.</creatorcontrib><creatorcontrib>Rijnberk, A.</creatorcontrib><title>Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) to suppression by a low dose of dexamethasone, but also elevated plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). Pituitary imaging with dynamic contrast-enhanced computed tomography demonstrated an enlarged pituitary gland and an adenoma. The cat underwent trans-sphenoidal hypophysectomy after which the insulin resistance disappeared. On histopathological and immunocytochemical examination of the surgical specimen a double adenoma was found, consisting of a corticotroph adenoma and a somatotroph adenoma separated by unaffected pituitary tissue.</description><subject>acromegaly</subject><subject>Adenoma - complications</subject><subject>Adenoma - pathology</subject><subject>Adenoma - veterinary</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Adrenocorticotropic Hormone - metabolism</subject><subject>alpha-MSH - blood</subject><subject>Animals</subject><subject>cat</subject><subject>Cat Diseases - pathology</subject><subject>Cat Diseases - physiopathology</subject><subject>Cats</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing Syndrome - veterinary</subject><subject>Cushing's disease</subject><subject>Diabetes Mellitus - etiology</subject><subject>Diabetes Mellitus - veterinary</subject><subject>double adenoma</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - metabolism</subject><subject>Hydrocortisone - blood</subject><subject>hypophysectomy</subject><subject>Insulin Resistance</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Male</subject><subject>man</subject><subject>pituitary</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Pituitary Neoplasms - veterinary</subject><subject>tumour</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaTYff6CHolNJDnZGsrWWIZewaZtCQgJtzkKWxkTL2nIkOW3-fbTZLb31JEa8z8vMQ8gnBiUDtjxfl2sz6ZIDVCW0JUD9jiyYqHhRMd6-JwsAzoq2bcQBOYxxDQBSCv6RHDCRmVqyBfnz0w86-RT89Ej1aOnKh-TM_uPepdklHV7opcUxJ-nplZ-7Df6dz6gbqaYrnehvlx7pldMdJoz0FjebDMe3zuuXCYO2ISPmrd7F4Zh86PUm4sn-PSIP377-Wl0XN3fff6wubwpTCZ4K3uklVJZ1aLpa1kJqI5hly8ZqLuveCs6ZtK3gtodK9qyWDZMdoEBe6Uab6oh82fVOwT_NGJMaXDR5Oz2in6NqWANNzeoc5LugCT7GgL2aghvy7YqB2vpWa7X1rba-FbQq-87Q53373A1o_yF7wTlwsQtgvvHZYVDROBwNWhfQJGW9-1__Kz4Fko0</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Meij, B.P.</creator><creator>van der Vlugt-Meijer, R.H.</creator><creator>van den Ingh, T.S.G.A.M.</creator><creator>Rijnberk, A.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism</title><author>Meij, B.P. ; van der Vlugt-Meijer, R.H. ; van den Ingh, T.S.G.A.M. ; Rijnberk, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-2ba603d1becb48458ac51d167da284fd52218d952df038f148718b0e5e23a7ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>acromegaly</topic><topic>Adenoma - complications</topic><topic>Adenoma - pathology</topic><topic>Adenoma - veterinary</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Adrenocorticotropic Hormone - metabolism</topic><topic>alpha-MSH - blood</topic><topic>Animals</topic><topic>cat</topic><topic>Cat Diseases - pathology</topic><topic>Cat Diseases - physiopathology</topic><topic>Cats</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing Syndrome - veterinary</topic><topic>Cushing's disease</topic><topic>Diabetes Mellitus - etiology</topic><topic>Diabetes Mellitus - veterinary</topic><topic>double adenoma</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - metabolism</topic><topic>Hydrocortisone - blood</topic><topic>hypophysectomy</topic><topic>Insulin Resistance</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Male</topic><topic>man</topic><topic>pituitary</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Pituitary Neoplasms - veterinary</topic><topic>tumour</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meij, B.P.</creatorcontrib><creatorcontrib>van der Vlugt-Meijer, R.H.</creatorcontrib><creatorcontrib>van den Ingh, T.S.G.A.M.</creatorcontrib><creatorcontrib>Rijnberk, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meij, B.P.</au><au>van der Vlugt-Meijer, R.H.</au><au>van den Ingh, T.S.G.A.M.</au><au>Rijnberk, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>130</volume><issue>2</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><abstract>A 9-year-old castrated male European shorthair cat with insulin-resistant diabetes was referred with the preliminary diagnosis of pituitary-dependent hyperadrenocorticism, based on measurements of urinary corticoids. Further studies revealed not only resistance of plasma concentrations of cortisol, adrenocorticotropic hormone (ACTH) and α-melanocyte-stimulating hormone (α-MSH) to suppression by a low dose of dexamethasone, but also elevated plasma concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). Pituitary imaging with dynamic contrast-enhanced computed tomography demonstrated an enlarged pituitary gland and an adenoma. The cat underwent trans-sphenoidal hypophysectomy after which the insulin resistance disappeared. On histopathological and immunocytochemical examination of the surgical specimen a double adenoma was found, consisting of a corticotroph adenoma and a somatotroph adenoma separated by unaffected pituitary tissue.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15003481</pmid><doi>10.1016/j.jcpa.2003.09.004</doi><tpages>7</tpages></addata></record> |
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| subjects | acromegaly Adenoma - complications Adenoma - pathology Adenoma - veterinary Adrenocorticotropic Hormone - blood Adrenocorticotropic Hormone - metabolism alpha-MSH - blood Animals cat Cat Diseases - pathology Cat Diseases - physiopathology Cats Cushing Syndrome - etiology Cushing Syndrome - veterinary Cushing's disease Diabetes Mellitus - etiology Diabetes Mellitus - veterinary double adenoma Growth Hormone - blood Growth Hormone - metabolism Hydrocortisone - blood hypophysectomy Insulin Resistance Insulin-Like Growth Factor I - analysis Male man pituitary Pituitary Neoplasms - complications Pituitary Neoplasms - pathology Pituitary Neoplasms - veterinary tumour |
| title | Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism |
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