Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals
OBJECTIVE—Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in no...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2004-03, Vol.24 (3), p.e25-e28 |
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| container_title | Arteriosclerosis, thrombosis, and vascular biology |
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| creator | Devaraj, Sridevi Jialal, Ishwarlal Vega-López, Sonia |
| description | OBJECTIVE—Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice.
METHODS AND RESULTS—After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2%), LDL (12.4%), and non-high-density lipoprotein (HDL) cholesterol (7.8%) compared with baseline and compared with placebo OJ (P |
| doi_str_mv | 10.1161/01.ATV.0000120784.08823.99 |
| format | Article |
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METHODS AND RESULTS—After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2%), LDL (12.4%), and non-high-density lipoprotein (HDL) cholesterol (7.8%) compared with baseline and compared with placebo OJ (P <0.01). Apolipoprotein B levels were significantly decreased (9.5%) with sterol OJ. There were no significant changes in HDL cholesterol or triglycerides with the sterol OJ. While folate and B12 levels significantly increased, homocysteine levels were unchanged.
CONCLUSIONS—Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.0000120784.08823.99</identifier><identifier>PMID: 14764424</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Apolipoproteins B - blood ; Beverages ; Cholesterol - administration & dosage ; Cholesterol - analogs & derivatives ; Cholesterol - therapeutic use ; Cholesterol, LDL - blood ; Citrus ; Double-Blind Method ; Female ; Folic Acid - blood ; Food, Fortified ; Homocysteine - blood ; Humans ; Hypercholesterolemia - blood ; Hypercholesterolemia - drug therapy ; Male ; Middle Aged ; Phytosterols - administration & dosage ; Phytosterols - therapeutic use ; Sitosterols - administration & dosage ; Sitosterols - therapeutic use ; Stigmasterol - administration & dosage ; Stigmasterol - therapeutic use ; Treatment Outcome ; Vitamin B 12 - blood</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2004-03, Vol.24 (3), p.e25-e28</ispartof><rights>2004 American Heart Association, Inc.</rights><rights>Copyright American Heart Association, Inc. Mar 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4728-7a0f44f8babff86e5294f1063a5c3ffcf7e758cf27e4ed90717dbe8865fec3ac3</citedby><cites>FETCH-LOGICAL-c4728-7a0f44f8babff86e5294f1063a5c3ffcf7e758cf27e4ed90717dbe8865fec3ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14764424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devaraj, Sridevi</creatorcontrib><creatorcontrib>Jialal, Ishwarlal</creatorcontrib><creatorcontrib>Vega-López, Sonia</creatorcontrib><title>Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice.
METHODS AND RESULTS—After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2%), LDL (12.4%), and non-high-density lipoprotein (HDL) cholesterol (7.8%) compared with baseline and compared with placebo OJ (P <0.01). Apolipoprotein B levels were significantly decreased (9.5%) with sterol OJ. There were no significant changes in HDL cholesterol or triglycerides with the sterol OJ. While folate and B12 levels significantly increased, homocysteine levels were unchanged.
CONCLUSIONS—Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen.</description><subject>Adult</subject><subject>Aged</subject><subject>Apolipoproteins B - blood</subject><subject>Beverages</subject><subject>Cholesterol - administration & dosage</subject><subject>Cholesterol - analogs & derivatives</subject><subject>Cholesterol - therapeutic use</subject><subject>Cholesterol, LDL - blood</subject><subject>Citrus</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Food, Fortified</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phytosterols - administration & dosage</subject><subject>Phytosterols - therapeutic use</subject><subject>Sitosterols - administration & dosage</subject><subject>Sitosterols - therapeutic use</subject><subject>Stigmasterol - administration & dosage</subject><subject>Stigmasterol - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Vitamin B 12 - blood</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtu1DAQhiMEoqXwCsjqBXdJfYwd7qpVy7ZaVCQKt1bWGbMu3mSxk1Yr8fDMHqSV8M2M5W8O_v-iuGS0YqxmV5RV148_K4qHcaqNrKgxXFRN86o4Z4rLUtaifo051U2pasnPinc5PyEvOadvizMmdS0ll-fF32-x7UfyfYQ0xPJ2SGPwATrykNr-F5D7KTggN96DG8MzxC1ZDC-QMpmthgh5X0UWgC-ZhJ58DbFDZr7dQHInAtbBkTm0cVxtyV3fhefQTW3M74s3HgN8OMaL4sftzeNsXi4evtzNrhelk5qbUrfUS-nNsl16b2pQvJGe0Vq0ygnvndeglXGea5DQNVQz3S3BmFrh2qJ14qL4dOi7ScOfCZey65AdRPw6DFO2WECVEgzBy__Ap2FKPe5mOWpntFESoc8HyKUh5wTeblJYt2lrGbU7gyxlFg2yJ4Ps3iDbNFj88ThhWq6hO5UeHUFAHoCXIaJ4-XecUHC72qu3aylFTVXJMaECr-VuiBH_AK0Enqw</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Devaraj, Sridevi</creator><creator>Jialal, Ishwarlal</creator><creator>Vega-López, Sonia</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals</title><author>Devaraj, Sridevi ; Jialal, Ishwarlal ; Vega-López, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4728-7a0f44f8babff86e5294f1063a5c3ffcf7e758cf27e4ed90717dbe8865fec3ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apolipoproteins B - blood</topic><topic>Beverages</topic><topic>Cholesterol - administration & dosage</topic><topic>Cholesterol - analogs & derivatives</topic><topic>Cholesterol - therapeutic use</topic><topic>Cholesterol, LDL - blood</topic><topic>Citrus</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Folic Acid - blood</topic><topic>Food, Fortified</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phytosterols - administration & dosage</topic><topic>Phytosterols - therapeutic use</topic><topic>Sitosterols - administration & dosage</topic><topic>Sitosterols - therapeutic use</topic><topic>Stigmasterol - administration & dosage</topic><topic>Stigmasterol - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Vitamin B 12 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devaraj, Sridevi</creatorcontrib><creatorcontrib>Jialal, Ishwarlal</creatorcontrib><creatorcontrib>Vega-López, Sonia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devaraj, Sridevi</au><au>Jialal, Ishwarlal</au><au>Vega-López, Sonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2004-03</date><risdate>2004</risdate><volume>24</volume><issue>3</issue><spage>e25</spage><epage>e28</epage><pages>e25-e28</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><abstract>OBJECTIVE—Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice.
METHODS AND RESULTS—After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2%), LDL (12.4%), and non-high-density lipoprotein (HDL) cholesterol (7.8%) compared with baseline and compared with placebo OJ (P <0.01). Apolipoprotein B levels were significantly decreased (9.5%) with sterol OJ. There were no significant changes in HDL cholesterol or triglycerides with the sterol OJ. While folate and B12 levels significantly increased, homocysteine levels were unchanged.
CONCLUSIONS—Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>14764424</pmid><doi>10.1161/01.ATV.0000120784.08823.99</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Apolipoproteins B - blood Beverages Cholesterol - administration & dosage Cholesterol - analogs & derivatives Cholesterol - therapeutic use Cholesterol, LDL - blood Citrus Double-Blind Method Female Folic Acid - blood Food, Fortified Homocysteine - blood Humans Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Male Middle Aged Phytosterols - administration & dosage Phytosterols - therapeutic use Sitosterols - administration & dosage Sitosterols - therapeutic use Stigmasterol - administration & dosage Stigmasterol - therapeutic use Treatment Outcome Vitamin B 12 - blood |
| title | Plant Sterol-Fortified Orange Juice Effectively Lowers Cholesterol Levels in Mildly Hypercholesterolemic Healthy Individuals |
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