Intrinsic Lipid Preferences and Kinetic Mechanism of Escherichia coli MurG

MurG, the last enzyme involved in the intracellular phase of peptidoglycan synthesis, is a membrane-associated glycosyltransferase that couples N-acetyl glucosamine to the C4 hydroxyl of a lipid-linked N-acetyl muramic acid derivative (lipid I) to form the β-linked disaccharide (lipid II) that is th...

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Veröffentlicht in:	Biochemistry (Easton) 2002-05, Vol.41 (21), p.6824-6833
Hauptverfasser:	Chen, Lan, Men, Hongbin, Ha, Sha, Ye, Xiang-Yang, Brunner, Livia, Hu, Yanan, Walker, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins Catalysis Escherichia coli - enzymology Glycosyltransferases - metabolism Kinetics Lipid Metabolism Lipids - chemistry Membrane Proteins - metabolism Monosaccharides - metabolism N-Acetylglucosaminyltransferases - metabolism Oligopeptides - metabolism Peptidoglycan - biosynthesis Substrate Specificity Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives Uridine Diphosphate N-Acetylmuramic Acid - metabolism
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