Increased local vascular endothelial growth factor expression associated with antitumor activity of proteasome inhibitor

Inhibition of the proteasome, a multicatalytic proteinase complex, is an attractive approach to cancer therapy. Here we report that a selective inhibitor of the chymotrypsin-like activity of the proteasome, PSI (N-benzyloxycarbonyl-Ile-Glu(O-t-butyl)-Ala-leucinal) may inhibit growth of solid tumors...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Apoptosis (London) 2004-03, Vol.9 (2), p.193-204
Hauptverfasser:	Stokłosa, T, Gołab, J, Wójcik, C, Włodarski, P, Jalili, A, Januszko, P, Giermasz, A, Wilczyński, G M, Pleban, E, Marczak, M, Wilk, S, Jakóbisiak, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Animals Cancer Carcinoma, Lewis Lung - drug therapy Colonic Neoplasms - drug therapy Mice Oligopeptides - pharmacology Oligopeptides - therapeutic use Proteasome Inhibitors Proteins Rodents Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!