Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study

Crohn's disease is a heterogeneous disorder for which NOD2 (CARD 15) has been identified as a susceptibility gene. We investigate the relation between NOD2 genotype and phenotypic characteristics of patients with Crohn's disease. Hypotheses about the relation between NOD2 genotype and Croh...

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Veröffentlicht in:	The Lancet (British edition) 2002-05, Vol.359 (9318), p.1661-1665
Hauptverfasser:	Hampe, Jochen, Grebe, Jochen, Nikolaus, Susanna, Solberg, Camilla, Croucher, Peter JP, Mascheretti, Silvia, Jahnsen, Jörgen, Moum, Björn, Klump, Bodo, Krawczak, Michael, Mirza, Muddassar M, Foelsch, Ulrich R, Vatn, Morten, Schreiber, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bowel disease Carrier Proteins - genetics Chi-Square Distribution Chromosomes, Human, Pair 16 Cloning Cohort Studies Crohn Disease - genetics Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Genetic Predisposition to Disease Genetics Genotype Germany Haplotypes Humans Immune response Intracellular Signaling Peptides and Proteins Male Medical sciences Nod2 Signaling Adaptor Protein Norway Other diseases. Semiology Phenotype Retrospective Studies Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Zusammenfassung:	Crohn's disease is a heterogeneous disorder for which NOD2 (CARD 15) has been identified as a susceptibility gene. We investigate the relation between NOD2 genotype and phenotypic characteristics of patients with Crohn's disease. Hypotheses about the relation between NOD2 genotype and Crohn's disease phenotype were generated retrospectively from a group of 446 German patients with this disorder. Positive findings (p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(02)08590-2