Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration

Hyperinsulinemia/insulin resistance and elevated plasma free fatty acids (FFA) levels are involved in the hypertension and cardiac sympathetic overactivity. Metformin improves insulin action and lower plasma FFA concentrations. We investigate the possible effect of metformin on arterial blood pressu...

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Veröffentlicht in:	American journal of hypertension 2004-03, Vol.17 (3), p.223-227
Hauptverfasser:	Manzella, Daniela, Grella, Rodolfo, Esposito, Katherine, Giugliano, Dario, Barbagallo, Mario, Paolisso, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anthropometry Arterial hypertension. Arterial hypotension Autonomic Nervous System - drug effects Autonomic Nervous System - physiology Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood Glucose - drug effects Blood Glucose - metabolism blood pressure Blood Pressure - drug effects Blood Pressure - physiology Cardiology. Vascular system Diabetes Mellitus - drug therapy Diabetes Mellitus - physiopathology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Fatty Acids, Nonesterified - blood Female free fatty acids Glycated Hemoglobin A - drug effects Glycated Hemoglobin A - metabolism Heart Rate - drug effects Heart Rate - physiology heart rate variability Humans Hypoglycemic Agents - therapeutic use insulin resistance Male Medical sciences Metformin Metformin - therapeutic use Middle Aged Multivariate Analysis Obesity Treatment Outcome Triglycerides - blood
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