Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue
The matrix metalloproteinases (MMPs) have been implicated in the ovulatory process, but the specific roles of individual MMPs are unclear. This study examined the effect of the preovulatory gonadotropin surge on localization and regulation of MMP-2, MMP-14, and tissue inhibitor of metalloproteinases...
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| Veröffentlicht in: | Biology of reproduction 2002-06, Vol.66 (6), p.1627-1634 |
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| container_title | Biology of reproduction |
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| creator | BAKKE, Leanne J DOW, Mark P. D CASSAR, Carolyn A PETERS, Michael W PURSLEY, J. Richard SMITH, George W |
| description | The matrix metalloproteinases (MMPs) have been implicated in the ovulatory process, but the specific roles of individual MMPs
are unclear. This study examined the effect of the preovulatory gonadotropin surge on localization and regulation of MMP-2,
MMP-14, and tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA and MMP-2 and TIMP-2 activity in bovine preovulatory follicles
and new corpora lutea (CL). Ovaries containing ovulatory follicles or new CL were collected at approximately 0, 6, 12, 18,
24, and 48 h (CL) after a GnRH-induced gonadotropin surge. Messenger RNA for TIMP-2 and MMP-14 increased within 6 and 24 h
of the gonadotropin surge, respectively, whereas MMP-2 mRNA was constitutively expressed. Activity for MMP-2 in follicular
fluid and follicle homogenates was not changed, but follicular fluid TIMP-2 activity increased in response to the gonadotropin
surge. Messenger RNA for MMP-2 was localized to the thecal layer of bovine preovulatory follicles, whereas MMP-14 mRNA was
localized primarily to the thecal layer and adjacent ovarian stroma. Expression of MMP-14 was also observed in the granulosal
layer after the gonadotropin surge. In contrast, TIMP-2 mRNA was localized predominantly to the granulosal layer with intense
expression in the antral portion of the granulosal layer in response to the gonadotropin surge. These data support the hypothesis
that increased expression of MMP-14 and TIMP-2 may help regulate follicle rupture and/or the ovulatory follicle-CL transition
in cattle. |
| doi_str_mv | 10.1095/biolreprod66.6.1627 |
| format | Article |
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are unclear. This study examined the effect of the preovulatory gonadotropin surge on localization and regulation of MMP-2,
MMP-14, and tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA and MMP-2 and TIMP-2 activity in bovine preovulatory follicles
and new corpora lutea (CL). Ovaries containing ovulatory follicles or new CL were collected at approximately 0, 6, 12, 18,
24, and 48 h (CL) after a GnRH-induced gonadotropin surge. Messenger RNA for TIMP-2 and MMP-14 increased within 6 and 24 h
of the gonadotropin surge, respectively, whereas MMP-2 mRNA was constitutively expressed. Activity for MMP-2 in follicular
fluid and follicle homogenates was not changed, but follicular fluid TIMP-2 activity increased in response to the gonadotropin
surge. Messenger RNA for MMP-2 was localized to the thecal layer of bovine preovulatory follicles, whereas MMP-14 mRNA was
localized primarily to the thecal layer and adjacent ovarian stroma. Expression of MMP-14 was also observed in the granulosal
layer after the gonadotropin surge. In contrast, TIMP-2 mRNA was localized predominantly to the granulosal layer with intense
expression in the antral portion of the granulosal layer in response to the gonadotropin surge. These data support the hypothesis
that increased expression of MMP-14 and TIMP-2 may help regulate follicle rupture and/or the ovulatory follicle-CL transition
in cattle.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod66.6.1627</identifier><identifier>PMID: 12021040</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Cattle - metabolism ; Corpus Luteum - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Luteinizing Hormone - metabolism ; Mammalian female genital system ; Matrix Metalloproteinase 2 - genetics ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinases, Membrane-Associated ; Metalloendopeptidases - genetics ; Metalloendopeptidases - metabolism ; Morphology. Physiology ; Ovarian Follicle - metabolism ; Ovulation - physiology ; RNA, Messenger - analysis ; Tissue Inhibitor of Metalloproteinase-2 - genetics ; Tissue Inhibitor of Metalloproteinase-2 - metabolism ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 2002-06, Vol.66 (6), p.1627-1634</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13674420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12021040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAKKE, Leanne J</creatorcontrib><creatorcontrib>DOW, Mark P. D</creatorcontrib><creatorcontrib>CASSAR, Carolyn A</creatorcontrib><creatorcontrib>PETERS, Michael W</creatorcontrib><creatorcontrib>PURSLEY, J. Richard</creatorcontrib><creatorcontrib>SMITH, George W</creatorcontrib><title>Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The matrix metalloproteinases (MMPs) have been implicated in the ovulatory process, but the specific roles of individual MMPs
are unclear. This study examined the effect of the preovulatory gonadotropin surge on localization and regulation of MMP-2,
MMP-14, and tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA and MMP-2 and TIMP-2 activity in bovine preovulatory follicles
and new corpora lutea (CL). Ovaries containing ovulatory follicles or new CL were collected at approximately 0, 6, 12, 18,
24, and 48 h (CL) after a GnRH-induced gonadotropin surge. Messenger RNA for TIMP-2 and MMP-14 increased within 6 and 24 h
of the gonadotropin surge, respectively, whereas MMP-2 mRNA was constitutively expressed. Activity for MMP-2 in follicular
fluid and follicle homogenates was not changed, but follicular fluid TIMP-2 activity increased in response to the gonadotropin
surge. Messenger RNA for MMP-2 was localized to the thecal layer of bovine preovulatory follicles, whereas MMP-14 mRNA was
localized primarily to the thecal layer and adjacent ovarian stroma. Expression of MMP-14 was also observed in the granulosal
layer after the gonadotropin surge. In contrast, TIMP-2 mRNA was localized predominantly to the granulosal layer with intense
expression in the antral portion of the granulosal layer in response to the gonadotropin surge. These data support the hypothesis
that increased expression of MMP-14 and TIMP-2 may help regulate follicle rupture and/or the ovulatory follicle-CL transition
in cattle.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle - metabolism</subject><subject>Corpus Luteum - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Mammalian female genital system</subject><subject>Matrix Metalloproteinase 2 - genetics</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinases, Membrane-Associated</subject><subject>Metalloendopeptidases - genetics</subject><subject>Metalloendopeptidases - metabolism</subject><subject>Morphology. Physiology</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovulation - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - genetics</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkd1uFCEYhonR2LV6BSaGE40mnZWfGegcarOtTXZjE2s8nADzTQfDwhaYbnuN3pS03WYPegQkD-_z8YLQe0rmlLTNV22Di7CJoRdiLuZUMPkCzWjD2koycfwSzQghouJc8AP0JqW_hNCaM_4aHVBGGCU1maF_i2EAk3EYcB4BX0QIN5NTOcQ7fBa86kOOYWM9_jXFK8DB45XK0d7iFWTlXCj6DNarBPjzanXxpaL1ES6bih1h5Xt8aVOaAJ_70WpbUu9Fz66miuHF7SZCSrYY_tg8FuP3cGN9GQmi3c90GpyzppziQ_xyyqDczvIWvRqUS_Butx6i36eLy5Mf1fLn2fnJt2U1llpyKUeZujlmTLWKEd6zutZSNlT1A2-lBqbbRmvKTcNk0xpjFIeGGkE1I7Uwkh-iT4-55QXXE6TcrW0y4JzyEKbUSSoJ5S0p4IcdOOk19N0m2rWKd91T_QX4uANUMsoNUXlj057jQtY1I3vjaK_GrY3QpXWpsMTybrvdCtGJ7v7_-X92k6a-</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>BAKKE, Leanne J</creator><creator>DOW, Mark P. D</creator><creator>CASSAR, Carolyn A</creator><creator>PETERS, Michael W</creator><creator>PURSLEY, J. Richard</creator><creator>SMITH, George W</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue</title><author>BAKKE, Leanne J ; DOW, Mark P. D ; CASSAR, Carolyn A ; PETERS, Michael W ; PURSLEY, J. Richard ; SMITH, George W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-72ac45822a9a203d244b7751adf397be2b95bb13c52759ccca3e51c61b2046c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle - metabolism</topic><topic>Corpus Luteum - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Mammalian female genital system</topic><topic>Matrix Metalloproteinase 2 - genetics</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinases, Membrane-Associated</topic><topic>Metalloendopeptidases - genetics</topic><topic>Metalloendopeptidases - metabolism</topic><topic>Morphology. Physiology</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovulation - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - genetics</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAKKE, Leanne J</creatorcontrib><creatorcontrib>DOW, Mark P. D</creatorcontrib><creatorcontrib>CASSAR, Carolyn A</creatorcontrib><creatorcontrib>PETERS, Michael W</creatorcontrib><creatorcontrib>PURSLEY, J. Richard</creatorcontrib><creatorcontrib>SMITH, George W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAKKE, Leanne J</au><au>DOW, Mark P. D</au><au>CASSAR, Carolyn A</au><au>PETERS, Michael W</au><au>PURSLEY, J. Richard</au><au>SMITH, George W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>66</volume><issue>6</issue><spage>1627</spage><epage>1634</epage><pages>1627-1634</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The matrix metalloproteinases (MMPs) have been implicated in the ovulatory process, but the specific roles of individual MMPs
are unclear. This study examined the effect of the preovulatory gonadotropin surge on localization and regulation of MMP-2,
MMP-14, and tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA and MMP-2 and TIMP-2 activity in bovine preovulatory follicles
and new corpora lutea (CL). Ovaries containing ovulatory follicles or new CL were collected at approximately 0, 6, 12, 18,
24, and 48 h (CL) after a GnRH-induced gonadotropin surge. Messenger RNA for TIMP-2 and MMP-14 increased within 6 and 24 h
of the gonadotropin surge, respectively, whereas MMP-2 mRNA was constitutively expressed. Activity for MMP-2 in follicular
fluid and follicle homogenates was not changed, but follicular fluid TIMP-2 activity increased in response to the gonadotropin
surge. Messenger RNA for MMP-2 was localized to the thecal layer of bovine preovulatory follicles, whereas MMP-14 mRNA was
localized primarily to the thecal layer and adjacent ovarian stroma. Expression of MMP-14 was also observed in the granulosal
layer after the gonadotropin surge. In contrast, TIMP-2 mRNA was localized predominantly to the granulosal layer with intense
expression in the antral portion of the granulosal layer in response to the gonadotropin surge. These data support the hypothesis
that increased expression of MMP-14 and TIMP-2 may help regulate follicle rupture and/or the ovulatory follicle-CL transition
in cattle.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>12021040</pmid><doi>10.1095/biolreprod66.6.1627</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of reproduction, 2002-06, Vol.66 (6), p.1627-1634 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71701390 |
| source | MEDLINE; BioOne Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Cattle - metabolism Corpus Luteum - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Luteinizing Hormone - metabolism Mammalian female genital system Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinases, Membrane-Associated Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Morphology. Physiology Ovarian Follicle - metabolism Ovulation - physiology RNA, Messenger - analysis Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Vertebrates: reproduction |
| title | Effect of the Preovulatory Gonadotropin Surge on Matrix Metalloproteinase (MMP)-14, MMP-2, and Tissue Inhibitor of Metalloproteinases-2 Expression Within Bovine Periovulatory Follicular and Luteal Tissue |
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