Genetic control of myeloproliferation in BXH-2 mice

While studying the unique Nramp1 (Slc11a1)–independent susceptibility to Mycobacterium bovis (BCG) infection of BXH-2 mice, we noted that these mice develop important splenomegaly and enlargement of lymph nodes. Segregation analyses in several F2 crosses showed that splenomegaly segregates as a sing...

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Veröffentlicht in:	Blood 2004-03, Vol.103 (6), p.2343-2350
Hauptverfasser:	Turcotte, Karine, Gauthier, Susan, Mitsos, Loukia-Maria, Shustik, Chaim, Copeland, Neal G., Jenkins, Nancy A., Fournet, Jean-Christophe, Jolicoeur, Paul, Gros, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Marrow - pathology Cation Transport Proteins - genetics Female Genetic Linkage Hematologic and hematopoietic diseases Leukemia Virus, Murine - growth & development Leukemia, Experimental - genetics Leukemia, Experimental - immunology Leukemia, Experimental - virology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Male Medical sciences Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mycobacterium bovis Retroviridae Infections - genetics Retroviridae Infections - immunology Spleen - pathology Splenomegaly - genetics Splenomegaly - pathology Tuberculosis - immunology Tumor Virus Infections - genetics Tumor Virus Infections - immunology Virus Replication
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