Neurofibromatosis type 1 tumour suppressor gene expression is deficient in psoriatic skin in vivo and in vitro: a potential link to increased Ras activity

Summary Background  Neurofibromatosis type 1 (NF1) protein (neurofibromin) accelerates the inactivation of Ras‐GTP in various cell types. Somatic mutations of the NF1 gene may lead to malignant transformation and uncontrolled proliferation. We have previously shown that NF1 protein expression is dow...

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