Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia
In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4....
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| Veröffentlicht in: | Antiviral therapy 2002-03, Vol.7 (1), p.31-35 |
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| container_title | Antiviral therapy |
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| creator | ALEXANDER, Christopher S MONTESSORI, Valentina WYNHOVEN, Brian DONG, Winnie CHAN, Keith O'SHAUGHNESSY, Michael V MO, Theresa PIASECZNY, Magda MONTANER, Julio S. G HARRIGAN, P. Richard |
| description | In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4.4% non-B virus. A range of different subtypes was identified, including one subtype A, 11 C, two D, five CRF01_AE, and one sample that could not be reliably subtyped. Baseline CD4 courts were significantly lower in individuals harbouring the non-B subtypes (P = 0.02), but baseline viral loads were similar (P = 0.80). In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months. |
| doi_str_mv | 10.1177/135965350200700104 |
| format | Article |
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In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months.</description><identifier>ISSN: 1359-6535</identifier><identifier>EISSN: 2040-2058</identifier><identifier>DOI: 10.1177/135965350200700104</identifier><identifier>PMID: 12008785</identifier><language>eng</language><publisher>London: International Medical Press</publisher><subject>Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - virology ; Adult ; Anti-HIV Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; CD4 Lymphocyte Count ; Drug Resistance, Viral - genetics ; Female ; HIV-1 - classification ; Humans ; Male ; Medical sciences ; Pharmacology. 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G</creatorcontrib><creatorcontrib>HARRIGAN, P. Richard</creatorcontrib><title>Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia</title><title>Antiviral therapy</title><addtitle>Antivir Ther</addtitle><description>In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4.4% non-B virus. A range of different subtypes was identified, including one subtype A, 11 C, two D, five CRF01_AE, and one sample that could not be reliably subtyped. Baseline CD4 courts were significantly lower in individuals harbouring the non-B subtypes (P = 0.02), but baseline viral loads were similar (P = 0.80). In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months.</description><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Adult</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>HIV-1 - classification</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Viral Load</subject><issn>1359-6535</issn><issn>2040-2058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1LxDAQhoMoun78AQ-Si96qk6TZtEdd_AJBD-q1JOkUI92kJu3CXv3ltuyCoKdh3nneOTyEnDK4ZEypKyZkOZdCAgdQAAzyHTLjkEPGQRa7ZDYB2UQckMOUPgF4UQLskwM2NgpVyBn5fom40i16i1T7mkZMXfAJaR_GvXcR-xhWLuqW9h8YdbemoaE--OyGpsH06w7TlDw8vlPn_1Qyr90Kx7x2K1cPuk0TcxNd79IHXYR2WBqnj8leM57wZDuPyNvd7eviIXt6vn9cXD9lVijRZ2WORaElt7mpWSkFGF5rYUAhNMqA1KzReVHXaPg8L21j0XKJluWWGcOUFUfkYvO3i-FrwNRXS5cstq32GIZUKTZK5CUfQb4BbQwpRWyqLrqljuuKQTWZr_6bH0tn2--DWWL9W9mqHoHzLaCT1W0Ttbcu_XJCzksFXPwAJ8-N6w</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>ALEXANDER, Christopher S</creator><creator>MONTESSORI, Valentina</creator><creator>WYNHOVEN, Brian</creator><creator>DONG, Winnie</creator><creator>CHAN, Keith</creator><creator>O'SHAUGHNESSY, Michael V</creator><creator>MO, Theresa</creator><creator>PIASECZNY, Magda</creator><creator>MONTANER, Julio S. G</creator><creator>HARRIGAN, P. Richard</creator><general>International Medical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia</title><author>ALEXANDER, Christopher S ; MONTESSORI, Valentina ; WYNHOVEN, Brian ; DONG, Winnie ; CHAN, Keith ; O'SHAUGHNESSY, Michael V ; MO, Theresa ; PIASECZNY, Magda ; MONTANER, Julio S. G ; HARRIGAN, P. 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Drug treatments</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALEXANDER, Christopher S</creatorcontrib><creatorcontrib>MONTESSORI, Valentina</creatorcontrib><creatorcontrib>WYNHOVEN, Brian</creatorcontrib><creatorcontrib>DONG, Winnie</creatorcontrib><creatorcontrib>CHAN, Keith</creatorcontrib><creatorcontrib>O'SHAUGHNESSY, Michael V</creatorcontrib><creatorcontrib>MO, Theresa</creatorcontrib><creatorcontrib>PIASECZNY, Magda</creatorcontrib><creatorcontrib>MONTANER, Julio S. G</creatorcontrib><creatorcontrib>HARRIGAN, P. 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Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia</atitle><jtitle>Antiviral therapy</jtitle><addtitle>Antivir Ther</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>7</volume><issue>1</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>1359-6535</issn><eissn>2040-2058</eissn><abstract>In North America, the B subtype of the major group (M) of HIV-1 predominates. Phylogenetic analysis of HIV reverse transcriptase and protease sequences isolated from 479 therapy-naive patients, first seeking treatment in British Columbia between June 1997 and August 1998, revealed a prevalence of 4.4% non-B virus. A range of different subtypes was identified, including one subtype A, 11 C, two D, five CRF01_AE, and one sample that could not be reliably subtyped. Baseline CD4 courts were significantly lower in individuals harbouring the non-B subtypes (P = 0.02), but baseline viral loads were similar (P = 0.80). In this study, individuals infected with non-B variants did not have a significantly different virological response to therapy after up to 18 months.</abstract><cop>London</cop><pub>International Medical Press</pub><pmid>12008785</pmid><doi>10.1177/135965350200700104</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - virology Adult Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 Lymphocyte Count Drug Resistance, Viral - genetics Female HIV-1 - classification Humans Male Medical sciences Pharmacology. Drug treatments Viral Load |
| title | Prevalence and response to antiretroviral therapy of non-B subtypes of HIV in antiretroviral-naive individuals in British Columbia |
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