P‐selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon γ and the IL‐13 decoy receptor

The selectin family of cell adhesion molecules is widely thought to promote inflammatory reactions by facilitating leukocyte recruitment. However, it was unexpectedly found that mice with targeted deletion of the P‐selectin gene (PsKO mice) developed unpolarized type 1/type 2 cytokine responses and...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2004-03, Vol.39 (3), p.676-687
Hauptverfasser:	Wynn, Thomas A., Hesse, Matthias, Sandler, Netanya G., Kaviratne, Mallika, Hoffmann, Karl F., Chiaramonte, Monica G., Reiman, Rachael, Cheever, Allen W., Sypek, Joseph P., Mentink‐Kane, Margaret M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biological and medical sciences Chronic Disease Cytokines - metabolism Eosinophilia - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Granuloma, Respiratory Tract - pathology Hepatitis - prevention & control Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin-13 Receptor alpha1 Subunit Liver Cirrhosis - pathology Liver Cirrhosis - prevention & control Lung Diseases - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout - genetics P-Selectin - genetics P-Selectin - metabolism Protein Isoforms - metabolism Receptors, Interleukin - metabolism Receptors, Interleukin-13 Schistosomiasis - metabolism
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