Subharmonic signal generation from contrast agents in simulated neovessels
Detection and measurement of blood flow in neovessels around a tumor can yield prognostic information about the tumor. Early detection and classification may help differentiate benign and malignant tumors; thus, improving patient management. This can be accomplished by injecting ultrasonic contrast...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2004-02, Vol.30 (2), p.199-203 |
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| container_title | Ultrasound in medicine & biology |
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| creator | Bhagavatheeshwaran, Govind Shi, William T Forsberg, Flemming Shankar, P.M |
| description | Detection and measurement of blood flow in neovessels around a tumor can yield prognostic information about the tumor. Early detection and classification may help differentiate benign and malignant tumors; thus, improving patient management. This can be accomplished by injecting ultrasonic contrast agents and measuring the backscattered signals from them. Use of the subharmonic backscattered signals from these agents may be better than fundamental or second harmonic components because of the negligible subharmonics generated by the surrounding tissue. Preliminary results on the detection and measurement of subharmonic signal components up to 12 dB (at increasing pressures) from very small tubes (200 to 300 μm diameter) are reported, demonstrating the possibility and potential application of subharmonic imaging in detecting tumor angiogenesis. (E-mail: pshankar@coe.drexel.edu) |
| doi_str_mv | 10.1016/j.ultrasmedbio.2003.10.016 |
| format | Article |
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Early detection and classification may help differentiate benign and malignant tumors; thus, improving patient management. This can be accomplished by injecting ultrasonic contrast agents and measuring the backscattered signals from them. Use of the subharmonic backscattered signals from these agents may be better than fundamental or second harmonic components because of the negligible subharmonics generated by the surrounding tissue. Preliminary results on the detection and measurement of subharmonic signal components up to 12 dB (at increasing pressures) from very small tubes (200 to 300 μm diameter) are reported, demonstrating the possibility and potential application of subharmonic imaging in detecting tumor angiogenesis. 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(E-mail: pshankar@coe.drexel.edu)</description><subject>Albumins</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Contrast agents</subject><subject>Contrast Media</subject><subject>Fluorocarbons</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neoplasms - blood supply</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neovascularization, Pathologic - diagnostic imaging</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Scattering, Radiation</subject><subject>Subharmonic signals</subject><subject>Technology. Biomaterials. Equipments. Material. 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| ispartof | Ultrasound in medicine & biology, 2004-02, Vol.30 (2), p.199-203 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Albumins Biological and medical sciences Blood Flow Velocity Contrast agents Contrast Media Fluorocarbons Humans Medical sciences Neoplasms - blood supply Neoplasms - diagnostic imaging Neovascularization, Pathologic - diagnostic imaging Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Scattering, Radiation Subharmonic signals Technology. Biomaterials. Equipments. Material. Instrumentation Tumor angiogenesis Ultrasonography |
| title | Subharmonic signal generation from contrast agents in simulated neovessels |
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