Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue
Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This f...
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| Veröffentlicht in: | The Journal of Medical Investigation 2004, Vol.51(1,2), pp.20-28 |
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| container_title | The Journal of Medical Investigation |
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| creator | Kajimoto, Kazuaki Yamazaki, Naoshi Kataoka, Masatoshi Terada, Hiroshi Shinohara, Yasuo |
| description | Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. In this review article, in addition to providing a brief introduction to the functional properties of BAT and UCP, we also describe and discuss properties of cultured brown adipocytes and the results of our exploratory studies on protein components involved in the energy-dissipating function in BAT. |
| doi_str_mv | 10.2152/jmi.51.20 |
| format | Article |
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It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. 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Med. Invest.</addtitle><description>Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. 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Med. Invest.</addtitle><date>2004-02</date><risdate>2004</risdate><volume>51</volume><issue>1,2</issue><spage>20</spage><epage>28</epage><pages>20-28</pages><issn>1343-1420</issn><eissn>1349-6867</eissn><abstract>Brown adipose tissue (BAT) is believed to function by dissipating excess energy in mammals. It is very important to understand the energy metabolism held in BAT since disorder of its energy-dissipating function may cause obesity or lifestyle-related diseases such as hypertension and diabetes. This function in BAT is mainly attributable to uncoupling protein (UCP), specifically expressed in its mitochondria. This protein consumes excess energy as heat by dissipating the H+ gradient across the inner mitochondrial membrane that is utilized as a driving force for ATP synthesis. 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| source | J-STAGE Free; MEDLINE; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue, Brown - physiology Animals brown adipose tissue Calcium Channels - genetics Calcium Channels - physiology Carrier Proteins - genetics Carrier Proteins - physiology Energy Metabolism Gene Expression Profiling Humans Inositol 1,4,5-Trisphosphate Receptors Ion Channels Membrane Proteins - genetics Membrane Proteins - physiology mitochondria Mitochondrial Proteins Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Proteins - genetics Proteins - physiology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology Thermogenesis - genetics Thermogenesis - physiology uncoupling Uncoupling Protein 1 |
| title | Identification of possible protein machinery involved in the thermogenic function of brown adipose tissue |
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