Efficient down-regulation of cyclin A-associated activity and expression in suspended primary keratinocytes requires p21(Cip1)

When suspended in methylcellulose, primary mouse keratinocytes cease proliferation and differentiate. Suspension also reduces the activity of the cyclin-dependent kinase cdk2, an important cell cycle regulatory enzyme. To determine how suspension modulates these events, we examined its effects on wi...

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Veröffentlicht in:	Molecular cancer research 2004-02, Vol.2 (2), p.96-104
Hauptverfasser:	Hauser, Paul, Ma, Le, Agrawal, Deepak, Haura, Eric, Cress, W Douglas, Pledger, W Jackson
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Cycle Proteins - metabolism Cell Differentiation Cell Division Cells, Cultured Cyclin A - genetics Cyclin A - metabolism Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Cyclins - genetics Cyclins - metabolism DNA - genetics DNA - metabolism DNA-Binding Proteins - metabolism Down-Regulation E2F Transcription Factors Gene Deletion Keratinocytes - cytology Keratinocytes - enzymology Keratinocytes - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Protein Binding Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism
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