Proteomic analysis of skin irritation reveals the induction of HSP27 by sodium lauryl sulphate in human skin

Summary Background There is an increasing need for screening of mild irritants in vitro to reduce animal testing. Objectives Proteomics were used to search for new markers of which the expression changes after mild irritation. Methods Sodium lauryl sulphate (SLS) was applied topically on excised hum...

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Veröffentlicht in:	British journal of dermatology (1951) 2002-05, Vol.146 (5), p.777-785
Hauptverfasser:	Boxman, I.L.A., Hensbergen, P.J., Van Der Schors, R.C., Bruynzeel, D.P., Tensen, C.P., Ponec, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives - methods Biological and medical sciences Biomarkers - analysis Cell Nucleus - metabolism Culture Techniques Dermatitis, Contact - diagnosis Dermatitis, Contact - metabolism Dermatitis, Contact - pathology Dermatology Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Heat-Shock Proteins HSP27 Heat-Shock Proteins Humans Medical sciences Neoplasm Proteins - metabolism Proteome proteomics screening Skin involvement in other diseases. Miscellaneous. General aspects Sodium Dodecyl Sulfate - administration & dosage sodium lauryl sulphate
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