TNF α‐induced ras activation due to ethanol promotes hepatocyte proliferation independently of liver injury in the mouse

Tumor necrosis factor α (TNFα) has been shown to be both proapoptotic and mitogenic for hepatocytes and necessary for alcohol‐induced liver injury. Ras, a known proto‐oncogene, is very important in the regulation of cellular responses to TNFα. Therefore, the purpose of this study was to investigate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2004-03, Vol.39 (3), p.721-731
Hauptverfasser:	Isayama, Fuyumi, Froh, Matthias, Yin, Ming, Conzelmann, Lars O., Milton, Richard J., McKim, Stephen E., Wheeler, Michael D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Aldehydes - metabolism Animals Biological and medical sciences Cell Division - drug effects Drug Administration Schedule Drug toxicity and drugs side effects treatment Ethanol - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Genes, Dominant Genetic Vectors Hepatocytes - pathology Liver - drug effects Liver - pathology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Pharmacology. Drug treatments ras Proteins - antagonists & inhibitors ras Proteins - genetics ras Proteins - metabolism Staining and Labeling Superoxide Dismutase - genetics Superoxide Dismutase - pharmacology Toxicity: digestive system Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!