Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti‐inflammatory cytokine expression in mice

Hepatic ischemia/reperfusion injury is a clinically important problem. While the mechanisms of the initial event and subsequent neutrophil‐dependent injury are somewhat understood, little is known about the regulation of endogenous hepatoprotective effects on this injury. Interleukin 12 (IL‐12) play...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2004-03, Vol.39 (3), p.699-710
Hauptverfasser:	Takeuchi, Dan, Yoshidome, Hiroyuki, Kato, Atsushi, Ito, Hiroshi, Kimura, Fumio, Shimizu, Hiroaki, Ohtsuka, Masayuki, Morita, Yasuhiro, Miyazaki, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Chemokines, CC - metabolism Chemokines, CXC - metabolism Gastroenterology. Liver. Pancreas. Abdomen Interleukin-10 - antagonists & inhibitors Interleukin-18 - metabolism Interleukin-18 - pharmacology Interleukin-4 - antagonists & inhibitors Liver - metabolism Liver - pathology Liver Circulation Male Medical sciences Mice Mice, Inbred C57BL Neutrophil Infiltration NF-kappa B - metabolism Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology STAT6 Transcription Factor Trans-Activators - metabolism Transcription Factor AP-1 - metabolism
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