Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study)
In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve...
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| Veröffentlicht in: | The American journal of cardiology 2004-03, Vol.93 (5), p.636-639 |
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| container_title | The American journal of cardiology |
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| creator | Kandzari, David E Chu, Alan Brodie, Bruce R Stuckey, Thomas A Hermiller, James B Vetrovec, George W Hannan, Karen L Krucoff, Mitchell W Christenson, Robert H Gibbons, Raymond J Sigmon, Kristina N Garg, Jyostna Hasselblad, Victor Collins, Kenneth Harrington, Robert A Berger, Peter B Chronos, Nicholas A Hochman, Judith S Califf, Robert M |
| description | In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5°C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury. |
| doi_str_mv | 10.1016/j.amjcard.2003.11.038 |
| format | Article |
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Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5°C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2003.11.038</identifier><identifier>PMID: 14996598</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - methods ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Combined Modality Therapy ; Creatine Kinase - metabolism ; Creatine Kinase, MB Form ; Diseases of the cardiovascular system ; Feasibility Studies ; Female ; Heart attacks ; Humans ; Hypothermia, Induced - adverse effects ; Hypothermia, Induced - methods ; Isoenzymes - metabolism ; Male ; Medical procedures ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - metabolism ; Myocardial Infarction - therapy ; Myocardial Reperfusion Injury - diagnostic imaging ; Myocardial Reperfusion Injury - metabolism ; Myocardial Reperfusion Injury - prevention & control ; Pilot Projects ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5°C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.</description><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Combined Modality Therapy</subject><subject>Creatine Kinase - metabolism</subject><subject>Creatine Kinase, MB Form</subject><subject>Diseases of the cardiovascular system</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypothermia, Induced - adverse effects</subject><subject>Hypothermia, Induced - methods</subject><subject>Isoenzymes - metabolism</subject><subject>Male</subject><subject>Medical procedures</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial Reperfusion Injury - diagnostic imaging</subject><subject>Myocardial Reperfusion Injury - metabolism</subject><subject>Myocardial Reperfusion Injury - prevention & control</subject><subject>Pilot Projects</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Vascular system</topic><topic>Combined Modality Therapy</topic><topic>Creatine Kinase - metabolism</topic><topic>Creatine Kinase, MB Form</topic><topic>Diseases of the cardiovascular system</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypothermia, Induced - adverse effects</topic><topic>Hypothermia, Induced - methods</topic><topic>Isoenzymes - metabolism</topic><topic>Male</topic><topic>Medical procedures</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardial Reperfusion Injury - diagnostic imaging</topic><topic>Myocardial Reperfusion Injury - metabolism</topic><topic>Myocardial Reperfusion Injury - prevention & control</topic><topic>Pilot Projects</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. 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| fulltext | fulltext |
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| ispartof | The American journal of cardiology, 2004-03, Vol.93 (5), p.636-639 |
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| subjects | Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - methods Biological and medical sciences Cardiology Cardiology. Vascular system Combined Modality Therapy Creatine Kinase - metabolism Creatine Kinase, MB Form Diseases of the cardiovascular system Feasibility Studies Female Heart attacks Humans Hypothermia, Induced - adverse effects Hypothermia, Induced - methods Isoenzymes - metabolism Male Medical procedures Medical sciences Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - metabolism Myocardial Infarction - therapy Myocardial Reperfusion Injury - diagnostic imaging Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Pilot Projects Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tomography Tomography, Emission-Computed, Single-Photon Treatment Outcome |
| title | Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study) |
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