Post-training reversible inactivation of hippocampus reveals interference between memory systems
A post‐training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long‐Evans rats trained in one of two versions of a water plus‐maze task received post‐training intra‐hippocampal infusions of the local a...
Gespeichert in:
| Veröffentlicht in: | Hippocampus 2002, Vol.12 (2), p.280-284 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 284 |
|---|---|
| container_issue | 2 |
| container_start_page | 280 |
| container_title | Hippocampus |
| container_volume | 12 |
| creator | Schroeder, Jason P. Wingard, Jeffrey C. Packard, Mark G. |
| description | A post‐training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long‐Evans rats trained in one of two versions of a water plus‐maze task received post‐training intra‐hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 μl), or saline. Post‐training intra‐hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2‐h) post‐training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non‐mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post‐training memory consolidation period is sufficient to enhance response learning. Hippocampus 2002;12:280–284. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/hipo.10024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71692911</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71692911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3634-5687768b527ab1e110030e0fb417e2e2582a32bcd635a1d907d79ca27b1b8e573</originalsourceid><addsrcrecordid>eNp9kElP5DAQhS0EYr_MDxjlxAEpg8tO7OSIGLZRsxxYjsZOV8CQxBk7DfS_x70AN071SvreK9Uj5BfQP0ApO3iyvZurbIVsAi2LFKjgqzOd07QUHDbIVgjPlALklK6TDWA0LizbJA_XLgzp4LXtbPeYeHxFH6xpMLGdrgb7qgfrusTVSbzSu0q3_STMMd2EyAzoa_TYVZgYHN4Qu6TF1vlpEqZhwDbskLU6ori7nNvk9uT45ugsHV2dnh8djtKKC56luSikFIXJmdQGEOI7nCKtTQYSGbK8YJozU40FzzWMSyrHsqw0kwZMgbnk22Rvkdt793-CYVCtDRU2je7QTYKSIEpWAkRwfwFW3oXgsVa9t632UwVUzVpUsz7nKovw72XqxLQ4_kaXBUYAFsCbbXD6Q5Q6O7---gxNFx4bG3r_8mj_ooTkMlf3l6fq7t_FfTG6-KsE_wDz5ZDd</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71692911</pqid></control><display><type>article</type><title>Post-training reversible inactivation of hippocampus reveals interference between memory systems</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Schroeder, Jason P. ; Wingard, Jeffrey C. ; Packard, Mark G.</creator><creatorcontrib>Schroeder, Jason P. ; Wingard, Jeffrey C. ; Packard, Mark G.</creatorcontrib><description>A post‐training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long‐Evans rats trained in one of two versions of a water plus‐maze task received post‐training intra‐hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 μl), or saline. Post‐training intra‐hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2‐h) post‐training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non‐mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post‐training memory consolidation period is sufficient to enhance response learning. Hippocampus 2002;12:280–284. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 1050-9631</identifier><identifier>EISSN: 1098-1063</identifier><identifier>DOI: 10.1002/hipo.10024</identifier><identifier>PMID: 12000124</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Analysis of Variance ; Anesthetics, Local - pharmacology ; Animals ; Bupivacaine - pharmacology ; Conditioning (Psychology) - drug effects ; Conditioning (Psychology) - physiology ; dorsal hippocampus ; enhanced memory systems ; Hippocampus - physiology ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Memory - drug effects ; Memory - physiology ; Microinjections ; Rats ; Rats, Long-Evans ; reversible lesion technique</subject><ispartof>Hippocampus, 2002, Vol.12 (2), p.280-284</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3634-5687768b527ab1e110030e0fb417e2e2582a32bcd635a1d907d79ca27b1b8e573</citedby><cites>FETCH-LOGICAL-c3634-5687768b527ab1e110030e0fb417e2e2582a32bcd635a1d907d79ca27b1b8e573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhipo.10024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhipo.10024$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12000124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schroeder, Jason P.</creatorcontrib><creatorcontrib>Wingard, Jeffrey C.</creatorcontrib><creatorcontrib>Packard, Mark G.</creatorcontrib><title>Post-training reversible inactivation of hippocampus reveals interference between memory systems</title><title>Hippocampus</title><addtitle>Hippocampus</addtitle><description>A post‐training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long‐Evans rats trained in one of two versions of a water plus‐maze task received post‐training intra‐hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 μl), or saline. Post‐training intra‐hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2‐h) post‐training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non‐mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post‐training memory consolidation period is sufficient to enhance response learning. Hippocampus 2002;12:280–284. © 2002 Wiley‐Liss, Inc.</description><subject>Analysis of Variance</subject><subject>Anesthetics, Local - pharmacology</subject><subject>Animals</subject><subject>Bupivacaine - pharmacology</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Conditioning (Psychology) - physiology</subject><subject>dorsal hippocampus</subject><subject>enhanced memory systems</subject><subject>Hippocampus - physiology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Microinjections</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>reversible lesion technique</subject><issn>1050-9631</issn><issn>1098-1063</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElP5DAQhS0EYr_MDxjlxAEpg8tO7OSIGLZRsxxYjsZOV8CQxBk7DfS_x70AN071SvreK9Uj5BfQP0ApO3iyvZurbIVsAi2LFKjgqzOd07QUHDbIVgjPlALklK6TDWA0LizbJA_XLgzp4LXtbPeYeHxFH6xpMLGdrgb7qgfrusTVSbzSu0q3_STMMd2EyAzoa_TYVZgYHN4Qu6TF1vlpEqZhwDbskLU6ori7nNvk9uT45ugsHV2dnh8djtKKC56luSikFIXJmdQGEOI7nCKtTQYSGbK8YJozU40FzzWMSyrHsqw0kwZMgbnk22Rvkdt793-CYVCtDRU2je7QTYKSIEpWAkRwfwFW3oXgsVa9t632UwVUzVpUsz7nKovw72XqxLQ4_kaXBUYAFsCbbXD6Q5Q6O7---gxNFx4bG3r_8mj_ooTkMlf3l6fq7t_FfTG6-KsE_wDz5ZDd</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Schroeder, Jason P.</creator><creator>Wingard, Jeffrey C.</creator><creator>Packard, Mark G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Post-training reversible inactivation of hippocampus reveals interference between memory systems</title><author>Schroeder, Jason P. ; Wingard, Jeffrey C. ; Packard, Mark G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3634-5687768b527ab1e110030e0fb417e2e2582a32bcd635a1d907d79ca27b1b8e573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Analysis of Variance</topic><topic>Anesthetics, Local - pharmacology</topic><topic>Animals</topic><topic>Bupivacaine - pharmacology</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>Conditioning (Psychology) - physiology</topic><topic>dorsal hippocampus</topic><topic>enhanced memory systems</topic><topic>Hippocampus - physiology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Microinjections</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>reversible lesion technique</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, Jason P.</creatorcontrib><creatorcontrib>Wingard, Jeffrey C.</creatorcontrib><creatorcontrib>Packard, Mark G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hippocampus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeder, Jason P.</au><au>Wingard, Jeffrey C.</au><au>Packard, Mark G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-training reversible inactivation of hippocampus reveals interference between memory systems</atitle><jtitle>Hippocampus</jtitle><addtitle>Hippocampus</addtitle><date>2002</date><risdate>2002</risdate><volume>12</volume><issue>2</issue><spage>280</spage><epage>284</epage><pages>280-284</pages><issn>1050-9631</issn><eissn>1098-1063</eissn><abstract>A post‐training reversible lesion technique was used to examine the effects of neural inactivation of the dorsal hippocampus on place and response learning. Male Long‐Evans rats trained in one of two versions of a water plus‐maze task received post‐training intra‐hippocampal infusions of the local anesthetic drug bupivacaine (0.75% solution, 0.5 μl), or saline. Post‐training intra‐hippocampal infusions of bupivacaine attenuated acquisition of the place task and enhanced acquisition of the response task. Delayed (2‐h) post‐training infusions of bupivacaine did not affect retention in either task. The findings demonstrate (1) enhanced learning after reversible hippocampal lesions that is independent of treatment influences on non‐mnemonic factors, and (2) inactivation of the dorsal hippocampus during the post‐training memory consolidation period is sufficient to enhance response learning. Hippocampus 2002;12:280–284. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12000124</pmid><doi>10.1002/hipo.10024</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1050-9631 |
| ispartof | Hippocampus, 2002, Vol.12 (2), p.280-284 |
| issn | 1050-9631 1098-1063 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71692911 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Analysis of Variance Anesthetics, Local - pharmacology Animals Bupivacaine - pharmacology Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology dorsal hippocampus enhanced memory systems Hippocampus - physiology Male Maze Learning - drug effects Maze Learning - physiology Memory - drug effects Memory - physiology Microinjections Rats Rats, Long-Evans reversible lesion technique |
| title | Post-training reversible inactivation of hippocampus reveals interference between memory systems |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A50%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Post-training%20reversible%20inactivation%20of%20hippocampus%20reveals%20interference%20between%20memory%20systems&rft.jtitle=Hippocampus&rft.au=Schroeder,%20Jason%20P.&rft.date=2002&rft.volume=12&rft.issue=2&rft.spage=280&rft.epage=284&rft.pages=280-284&rft.issn=1050-9631&rft.eissn=1098-1063&rft_id=info:doi/10.1002/hipo.10024&rft_dat=%3Cproquest_cross%3E71692911%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71692911&rft_id=info:pmid/12000124&rfr_iscdi=true |