2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues

A series of 2'-alkylthio-2-(anilinomethyl)imidazolines were prepared to examine the effect of the alkyl group size, sulfur oxidation state, and phenyl ring substitution on ligand binding and agonism of alpha-adrenergic receptor subtypes alpha1a, alpha1b, alpha1d, alpha2a, and alpha2c. Binding a...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-05, Vol.45 (11), p.2229-2239
Hauptverfasser:	Hodson, Stephen J, Bishop, Michael J, Speake, Jason D, Navas, 3rd, Frank, Garrison, Deanna T, Bigham, Eric C, Saussy, Jr, David L, Liacos, James A, Irving, Paul E, Gobel, M Jeffrey, Sherman, Bryan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - chemical synthesis Adrenergic alpha-Agonists - chemistry Adrenergic alpha-Agonists - pharmacology Calcium - metabolism Cell Line Cyclic AMP - biosynthesis Fibroblasts - metabolism Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Receptors, Adrenergic, alpha-1 - drug effects Sulfones - chemical synthesis Sulfones - chemistry Sulfones - pharmacology
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