Biological Activity and Chemistry of Taxoids from the Japanese Yew, Taxus cuspidata
Approximately 120 taxoids have been isolated to date from the Japanese yew, Taxus cuspidata. These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-in...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-02, Vol.67 (2), p.245-256 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | SHIGEMORI, Hideyuki KOBAYASHI, Jun'ichi |
| description | Approximately 120 taxoids have been isolated to date from the Japanese yew, Taxus cuspidata. These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-induced depolymerization of microtubules, increase cellular accumulation of vincristine in multidrug-resistant tumor cells, and exhibit potent cytotoxicity. Chemical derivatization of taxoids of T. cuspidata is also reviewed. |
| doi_str_mv | 10.1021/np030346y |
| format | Article |
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These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-induced depolymerization of microtubules, increase cellular accumulation of vincristine in multidrug-resistant tumor cells, and exhibit potent cytotoxicity. 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Nat. Prod</addtitle><description>Approximately 120 taxoids have been isolated to date from the Japanese yew, Taxus cuspidata. These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-induced depolymerization of microtubules, increase cellular accumulation of vincristine in multidrug-resistant tumor cells, and exhibit potent cytotoxicity. Chemical derivatization of taxoids of T. cuspidata is also reviewed.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Paclitaxel - chemistry</subject><subject>Paclitaxel - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Taxoids - chemistry</subject><subject>Taxoids - pharmacology</subject><subject>Taxus - chemistry</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0L1OwzAUBWALgWgpDLwA8gITATv-H0uBAqqgUosQU-Q4DjWkSYgTaN6eVC0w3eF8ujo6ABxjdIFRiC_zEhFEKG93QB-zEAUchWwX9BHmJCCS0x448P4doY4ptg96mCopEOd9MLtyRVa8OaMzODS1-3J1C3WewNHCLp2vqxYWKZzrVeESD9OqWMJ6YeGDLnVuvYWv9vt8HTcemsaXLtG1PgR7qc68PdreAXi-vZmP7oLJ0_h-NJwEjlBcB0RrJQ3hlGGCJDYyYYhgRLGlPKSCSGtirgWJGUmUpAiJmHGlUhrHcaINIwNwtvlbVsVnY30ddY2NzbKuWtH4SGCucChUB0-2sImXNonKyi111Ua_M3TgdAu075ZIK50b5_8dYyFXYu2CjeuWsau_XFcfERdEsGg-nUUv6lHi8VRG1-QHa0N5DA</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>SHIGEMORI, Hideyuki</creator><creator>KOBAYASHI, Jun'ichi</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Biological Activity and Chemistry of Taxoids from the Japanese Yew, Taxus cuspidata</title><author>SHIGEMORI, Hideyuki ; KOBAYASHI, Jun'ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i341t-3aa98c364513081c8d5031041e4624738ecb6a73b53d984007b5699f4bbbdac53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Paclitaxel - chemistry</topic><topic>Paclitaxel - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plants, Medicinal - chemistry</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>Taxoids - chemistry</topic><topic>Taxoids - pharmacology</topic><topic>Taxus - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIGEMORI, Hideyuki</creatorcontrib><creatorcontrib>KOBAYASHI, Jun'ichi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIGEMORI, Hideyuki</au><au>KOBAYASHI, Jun'ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological Activity and Chemistry of Taxoids from the Japanese Yew, Taxus cuspidata</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>67</volume><issue>2</issue><spage>245</spage><epage>256</epage><pages>245-256</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Approximately 120 taxoids have been isolated to date from the Japanese yew, Taxus cuspidata. These taxoids possess various skeletons containing 5/7/6-, 6/10/6-, 6/5/5/6-, 6/8/6-, or 6/12-membered ring systems. Among the taxoids, some non-paclitaxel-type compounds have been shown to reduce CaCl(2)-induced depolymerization of microtubules, increase cellular accumulation of vincristine in multidrug-resistant tumor cells, and exhibit potent cytotoxicity. Chemical derivatization of taxoids of T. cuspidata is also reviewed.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>14987066</pmid><doi>10.1021/np030346y</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2004-02, Vol.67 (2), p.245-256 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences General pharmacology Medical sciences Molecular Structure Paclitaxel - chemistry Paclitaxel - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Stereoisomerism Structure-Activity Relationship Taxoids - chemistry Taxoids - pharmacology Taxus - chemistry |
| title | Biological Activity and Chemistry of Taxoids from the Japanese Yew, Taxus cuspidata |
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